TACI, Fc-Fusion (IgG1), Avi-Tag Recombinant
Recombinant human TACI (Tumor necrosis factor receptor superfamily member 13B, encoded by the TNFRSF13B gene), encompassing amino acids 23-166. This protein is fused at the C-terminus with the Fc fragment of human IgG1 followed by an Avi-Tag™. The recombinant protein was affinity purified.
≥90%
TACI is a lymphocyte-specific member of the TNF (Tumor necrosis factor) receptor superfamily, which regulates B and T cell function and humoral immunity. This receptor binds to ligands APRIL and BAFF, two ligands that also bind to BCMA (B-cell maturation antigen) to induce B cell proliferation. TACI induces antibody responses and plasma cell differentiation, and it counteracts BAFF-driven B cell activation. Upon ligand binding, TACI interacts with CAML (calcium-modulator and cyclophilin ligand) to promote calcineurin-dependent activation of transcription factor NFAT (Nuclear Factor of Activated T cells). Although they do not directly cause disease, mutations in the TNFRSF13B gene predispose patients with CVID (common variable immunodeficiency) to autoimmune and immune cell proliferation disorders.
- Coste, A.T., et al., Eukaryotic Cell. 2004; 3(6): 1639-1652.
- Smith, S.T. et al., Nature Cell Bio. 2004; 6: 162-167.
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