Protease(s)

 

Protease is the name given to a class of enzymes that catalyze protein catabolism by hydrolysis of the peptide bonds linking amino acids together. Proteases have evolved to perform these reactions by numerous different mechanisms and are found in animals, plants, bacteria, archaea, and viruses, highlighting the important role that they play in all forms of life on Earth. Proteases are involved in protein processing, regulation of protein function, apoptosis, viral pathogenesis, digestion, photosynthesis, and numerous other vital processes.

More recently, various industries have begun to take advantage of proteases as an active ingredient in specific products or as a research tool. For example, laundry detergents contain proteases to help break down stains; proteases are often added to bread during the baking process to help soften the final product; and the biotech industry takes advantage of highly specific proteases, such as TEV protease and thrombin, to cleave fusion proteins.

Proteases also offer a valuable target in many therapeutic settings, including Alzheimer’s, cancer, and viral infection. In fact, one of the most widely-used classes of anti-viral therapeutics is protease inhibitors, which are used to treat both HIV and HCV infections.

BPS offers a wide selection of purified proteases, assay kits, fluorogenic substrates, and inhibitors/activators to reach all your research needs. In addition, we also offer protease screening and profiling services if you prefer to take advantage of our screening experience and expertise in this area.

References:

1. Overall, C.M. & Kleifeld, O., Nat. Rev. Canc. 2006; 6: 227-239.
2. Turk, B., Nat. Rev. Drug Disc. 2006; 5: 785-799.
3. Anderson, J. et al., Handbook of Experimental Pharmacology. 2009; 189: 85-110.

 

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Catalog#SizeProduct NamePrice
80215 20 µg MMP9 (Q279R), His-tag
$425
27711 5 mg Nutlin-3
$215
27766-1 10 mg NVP-BEP800
$260
27766-2 5 mg NVP-BEP800
$180
27766-3 25 mg NVP-BEP800
$510
27044 5 mg Obatoclax
$120
27318 500 mg Oxyresveratrol
$580
27712-2 50 mg P22077
$495
27043 10 mg PAC-1
$160
27316 50 mg PCI 34051
$505
80106 96 reactions POP Assay Kit
$620
80105 20 µg Prolyl Oligopeptidase/Prolyl Endopeptidase, His-tag
$395
27716-3 50 mg PYR-41
$440
80201 100 µg Rat Renin, His-tag
$435
80211 96 reactions Renin Assay Kit
$325
80200 100 µg Renin, His-tag
$435
79392 3 units of Sortase SiMPLe Protein Labeling Kit (Sortase Mediated Protein Ligation)
$365
27106 200 mg Sitagliptin
$235
71046 50 µg Sortase A Pentamutant, S. aureus, His-tag
$490
71047 50 µg Sortase A, Hexamutant, His-Tag
$470
72518 50 µg Sortase A, Octamutant, His-Tag
$470
71086 50 µg Sortase A, S. aureus, His-tag
$490
71048 50 µg Sortase A, Septamutant, His-Tag
$470
79709 50 µg Sortase Sampling Kit
$650
27051 5 mg Telaprevir (VX-950)
$560

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