Protease(s)

 

Protease is the name given to a class of enzymes that catalyze protein catabolism by hydrolysis of the peptide bonds linking amino acids together. Proteases have evolved to perform these reactions by numerous different mechanisms and are found in animals, plants, bacteria, archaea, and viruses, highlighting the important role that they play in all forms of life on Earth. Proteases are involved in protein processing, regulation of protein function, apoptosis, viral pathogenesis, digestion, photosynthesis, and numerous other vital processes.

More recently, various industries have begun to take advantage of proteases as an active ingredient in specific products or as a research tool. For example, laundry detergents contain proteases to help break down stains; proteases are often added to bread during the baking process to help soften the final product; and the biotech industry takes advantage of highly specific proteases, such as TEV protease and thrombin, to cleave fusion proteins.

Proteases also offer a valuable target in many therapeutic settings, including Alzheimer’s, cancer, and viral infection. In fact, one of the most widely-used classes of anti-viral therapeutics is protease inhibitors, which are used to treat both HIV and HCV infections.

BPS offers a wide selection of purified proteases, assay kits, fluorogenic substrates, and inhibitors/activators to reach all your research needs. In addition, we also offer protease screening and profiling services if you prefer to take advantage of our screening experience and expertise in this area.

References:

1. Overall, C.M. & Kleifeld, O., Nat. Rev. Canc. 2006; 6: 227-239.
2. Turk, B., Nat. Rev. Drug Disc. 2006; 5: 785-799.
3. Anderson, J. et al., Handbook of Experimental Pharmacology. 2009; 189: 85-110.

 

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Catalog#SizeProduct NamePrice
80215 20 µg MMP9 (Q279R), His-tag
$415
27711 5 mg Nutlin-3
$210
27766-2 5 mg NVP-BEP800
$175
27766-3 25 mg NVP-BEP800
$495
27766-1 10 mg NVP-BEP800
$250
27044 5 mg Obatoclax
$115
27318 500 mg Oxyresveratrol
$565
27712-2 50 mg P22077
$480
27043 10 mg PAC-1
$155
27316 50 mg PCI 34051
$490
80106 96 reactions POP Assay Kit
$600
80105 20 µg Prolyl Oligopeptidase/Prolyl Endopeptidase, His-tag
$385
27716-3 50 mg PYR-41
$425
80201 100 µg Rat Renin, His-tag
$420
80211 96 reactions Renin Assay Kit
$315
80200 100 µg Renin, His-tag
$420
79392 3 units of Sortase SiMPLe Protein Labeling Kit (Sortase Mediated Protein Ligation)
$355
27106 200 mg Sitagliptin
$230
71046 50 µg Sortase A Pentamutant, S. aureus, His-tag
$475
71047 50 µg Sortase A, Hexamutant, His-Tag
$455
72518 50 µg Sortase A, Octamutant, His-Tag
$455
71086 50 µg Sortase A, S. aureus, His-tag
$475
71048 50 µg Sortase A, Septamutant, His-Tag
$455
27051 5 mg Telaprevir (VX-950)
$545
27721-2 500 mg Thalidomide
$310

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