Protease(s)

 

Protease is the name given to a class of enzymes that catalyze protein catabolism by hydrolysis of the peptide bonds linking amino acids together. Proteases have evolved to perform these reactions by numerous different mechanisms and are found in animals, plants, bacteria, archaea, and viruses, highlighting the important role that they play in all forms of life on Earth. Proteases are involved in protein processing, regulation of protein function, apoptosis, viral pathogenesis, digestion, photosynthesis, and numerous other vital processes.

More recently, various industries have begun to take advantage of proteases as an active ingredient in specific products or as a research tool. For example, laundry detergents contain proteases to help break down stains; proteases are often added to bread during the baking process to help soften the final product; and the biotech industry takes advantage of highly specific proteases, such as TEV protease and thrombin, to cleave fusion proteins.

Proteases also offer a valuable target in many therapeutic settings, including Alzheimer’s, cancer, and viral infection. In fact, one of the most widely-used classes of anti-viral therapeutics is protease inhibitors, which are used to treat both HIV and HCV infections.

BPS offers a wide selection of purified proteases, assay kits, fluorogenic substrates, and inhibitors/activators to reach all your research needs. In addition, we also offer protease screening and profiling services if you prefer to take advantage of our screening experience and expertise in this area.

References:

1. Overall, C.M. & Kleifeld, O., Nat. Rev. Canc. 2006; 6: 227-239.
2. Turk, B., Nat. Rev. Drug Disc. 2006; 5: 785-799.
3. Anderson, J. et al., Handbook of Experimental Pharmacology. 2009; 189: 85-110.

 

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Catalog#SizeProduct NamePrice
27318 500 mg Oxyresveratrol
$565
27712-2 50 mg P22077
$385
27043 10 mg PAC-1
$85
27316 50 mg PCI 34051
$490
80380 10 µg PrCP, His-tag
$435
80105 20 µg Prolyl Oligopeptidase/Prolyl Endopeptidase, His-tag
$385
27716-3 50 mg PYR-41
$390
80201 100 µg Rat Renin, His-tag
$420
80200 100 µg Renin, His-tag
$420
27106 200 mg Sitagliptin
$170
71046 50 µg Sortase A Pentamutant, S. aureus, His-tag
$475
71047 50 µg Sortase A, Hexamutant, His-Tag
$455
72518 50 µg Sortase A, Octamutant, His-Tag
$455
71086 50 µg Sortase A, S. aureus, His-tag
$475
71048 50 µg Sortase A, Septamutant, His-Tag
$455
27051 5 mg Telaprevir (VX-950)
$545
27721-2 500 mg Thalidomide
$215
27319 50 mg Trimidox
$405
27320 100 mg Trimidox
$695
50308 10000 units TurboTEV Protease
$435
27053 5 mg VX-222
$180
27314 5 mg Z-DEVD-FMK
$210
27313 5 mg Z-VAD(OMe)-FMK
$450
27017 1 mg Z-VAD-FMK, Methyl Ester
$140

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