Fluorogenic MALT1 Assay Kit
Catalog #
79809
$550
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Description
The Fluorogenic MALT1 Assay Kit is designed to measure MALT1 activity for screening and profiling applications, in a homogeneous assay with no time-consuming washing steps.
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Synonyms
IMD12, MLT, MLT1, PCASP1, MALT1 paracaspase
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Product Data Gallery
Product Info
Storage and Usage
Citations
Assay Kit Format
Fluorogenic
Species
Human
Supplied As
The MALT1 assay kit comes in a convenient 96-well format, with purified MALT1 enzyme, fluorogenic substrate, and MALT1 assay buffer for 100 enzyme reactions.
Materials Required But Not Supplied
Fluorescent microplate reader capable of reading exc/em=360nm/460nm
Format
| Catalog # | Component | Amount | Storage | |
| 100360 | Recombinant Human MALT1 | 30 µg | -80°C | Avoid freeze/ thaw cycles! |
| 79810 | 1 mM MALT1 Substrate | 100 µl | -80°C | |
| 79811 | 1X MALT1 Assay Buffer | 10 ml | -20°C | |
| 79685 | Black, low binding black microtiter plate | 1 | Room Temp | |
UniProt #
Q9UDY8
Background
MALT1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1) is a cysteine protease that structurally resembles caspases. MALT1 is a member of the CARMA1-BCL10-MALT1 (CBM) complex that mediates NF-κB activation downstream of the B cell receptor, T cell receptor and ITAM-coupled natural killer cell receptors. MALT1 cleavage activity is essential to T cell and B cell activation and is linked to the pathogenesis of activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL), a chemoresistant form of DLBCL.
References
Fontan, L. et al., Cancer Cell. 2012 Dec 11; 22(6): 812–824.
Nagel, D. et al., Cancer Cell. 2012 Dec 11;22(6):825-837.
Rebeaud, F. et al., Nat Immunol. 2008; 9:272-281
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