Custom Services Frequently Asked Questions
What kind of services does BPS Bioscience offer?
Development services: we develop custom recombinant proteins and new assays, generate cell lines overexpressing a target of interest or containing a reporter gene, and develop cells containing the CRISPR-mediated genetic modification(s) of your choice. In addition, we can assist you with the design and validation of a tailored chimeric antigen receptor (CAR) of interest, or with AAV (Adeno Associated Virus) or lentivirus development. Visit BPS Bioscience Services for more information.
Screening and Profiling:
Screening and Profiling:
- Biochemical Screening and profiling services: our full portfolio of >600 assays is available as a service: we perform screening, IC50 determination, and comparisons of drug efficacy across protein families. Visit Screening and Profiling Services to learn more.
- Cell-based screening services: characterize or titrate your drug in one or several cell lines. Cellular studies provide a biological context, allowing for more informed decisions about which compounds to advance to development. Visit Immunotherapy Screening Services
Can I receive guidance on development projects?
Absolutely. Our team of scientists will communicate with you throughout the project's design to ensure that the results correspond to what you need.
Does BPS Bioscience use a reference compound as internal control?
Yes. Our assays are validated with an internal control using a commercially available inhibitor whenever available. When several compounds have been used in an assay (visit the assay page), you can choose between them. Some assays may not have a commercially available reference inhibitor.
Alternatively, you may request that we use a reference compound of your choice. Please send your reference compound to us together with your test compounds, indicating clearly which compound is your reference.
Alternatively, you may request that we use a reference compound of your choice. Please send your reference compound to us together with your test compounds, indicating clearly which compound is your reference.
How do I submit a request?
Please use the contact form at the bottom of the Contact Us page, where you can provide your contact information and details about your project.
Make sure to include which target protein(s) you wish to study, how many compounds you have to test, and whether you need a single concentration assay or a full IC50.
Remember that if several reference compounds are available for an assay, you need to indicate which one(s) should be used as internal control(s). If you wish to use a different reference compound than the compound used by BPS, please send it to us together with your test compounds, indicating clearly which compound is your reference.
Alternatively:
Make sure to include which target protein(s) you wish to study, how many compounds you have to test, and whether you need a single concentration assay or a full IC50.
Remember that if several reference compounds are available for an assay, you need to indicate which one(s) should be used as internal control(s). If you wish to use a different reference compound than the compound used by BPS, please send it to us together with your test compounds, indicating clearly which compound is your reference.
Alternatively:
- Contact your Sales representative (US) at [email protected]
- International customers (non-US) should contact their local distributor. For a list of International Distributors, visit Worldwide Distributors
How should I prepare compounds?
Prior to shipping your compounds, please review our Compound Submission guidelines. Fill out a “Compound Submission Form” and include it with your compounds when shipping, in addition to sending it to the email address provided on the form.
Biochemical Assay Compound Submission Form
Cellular Assay Compound Submission Form
Remember that if several reference compounds are available for an assay, you need to indicate which one(s) should be used as internal control(s). If you wish to use a different reference compound than the compound used by BPS, please send it to us together with your test compounds, indicating clearly which compound is your reference.
Compound Preparation:
Biochemical Assay Compound Submission Form
Cellular Assay Compound Submission Form
Remember that if several reference compounds are available for an assay, you need to indicate which one(s) should be used as internal control(s). If you wish to use a different reference compound than the compound used by BPS, please send it to us together with your test compounds, indicating clearly which compound is your reference.
Compound Preparation:
- Biochemical assays: Prepare at least 50 µl of compound solution, at a concentration that is 100-fold higher than the highest concentration to be tested if the diluent is DMSO (dimethyl sulfoxide).
- Cellular assays: Prepare at least 50 µl of compound solution, at a concentration that is 1000-fold higher than the desired final concentration if the diluent is DMSO.
- Further dilution (if possible)
- Sonication
- Heat at 50°C
Where do I send compounds?
Mail your compounds to:
BPS Bioscience
ATTN: Compound Submissions
6405 Mira Mesa Blvd., Suite 100
San Diego, CA 92121
Phone: 858-202-1401
Once the package has been shipped, notify us of the tracking number, so we can monitor the shipment and ensure your compounds arrive safely.
BPS Bioscience
ATTN: Compound Submissions
6405 Mira Mesa Blvd., Suite 100
San Diego, CA 92121
Phone: 858-202-1401
Once the package has been shipped, notify us of the tracking number, so we can monitor the shipment and ensure your compounds arrive safely.
How are results communicated to me?
When a project has been completed, BPS Bioscience will provide you with an extensive report containing raw and analyzed data, graphs, and detailed protocols. Testing typically includes internal controls for inhibition. This report will be sent to you directly.
Can I have details on the protocol used for screening or profiling before ordering a service?
Yes. Our services correspond to existing assays, which can be viewed on our website. Open the datasheet corresponding to the assay you are interested in. All our assay kits are provided with detailed protocols and validation data, available from the datasheet.