BCKDK, GST-Tag Recombinant
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Catalog #
101115
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$340
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Description
Recombinant human BCKDK (Branched chain ketoacid dehydrogenase kinase), from amino acid 30 to end. In this construct the N-terminal end of the protein is fused to GST. The protein was affinity purified.
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Synonyms
BCKDKD, BDK, [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial, BCKDHKIN
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Product Info
Storage and Usage
Citations
Species
Human
Construct
BCKDK (GST-30-end)
Host Species/Expression System
Sf9
Purity
≥90%
Format
Aqueous buffer solution
Formulation
50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol
MW
69 kDa
Amino Acids
30-end
Genbank #
NM_005881
UniProt #
O14874
Background
BCKDK (Branched chain ketoacid dehydrogenase kinase) is a mitochondrial kinase found at high levels in skeletal muscle. BCKDK phosphorylates and inactivates BCKD, leading to an increase in branched amino acids. Abnormal activity of this enzyme leads to diseases such as maple syrup urine disease and cachexia.