Anti–BMI1 polyclonal antibody
Catalog #
25210
$335
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Description
Polyclonal antibody raised in rabbit against mouse BMI1 (BMI1 polycomb ring finger oncogene) using two KLHconjugated synthetic peptides containing a sequence from the central and the C–terminal region of the protein, respectively.
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Product Info
Storage and Usage
Citations
Clonality
polyclonal
Host Species/Expression System
Rabbit
Purification
Whole serum
Format
aqueous solution
Formulation
Whole antiserum from rabbit containing 0.05% azide
Concentration
100 µl
Immunogen
synthetic peptide
Background
BMI1 (UniProtKB/Swiss–Prot entry P35226) is a component of a Polycomb group (PcG) multiprotein PRC1–like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. The PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of lysine 119 on histone H2A, rendering chromatin heritably changed in its expressibility. BMI1 is required to stimulate the E3 ubiquitin–protein ligase activity of RNF2/RING2 in the PRC1 complex.