p53, GST-Tag Recombinant
Recombinant human p53 (Cellular tumor antigen p53), full length, encompassing amino acids 2-393(end). This construct contains an N-terminal GST-tag followed by a an optimal TEV protease target sequence that allows cleavage of GST (TEV: tobacco etch virus cysteine protease BPS Bioscience #50308). The recombinant protein was affinity purified.
≥82%
40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, 3 mM DTT, 20% glycerol, and variable glutathione
p53 is a transcription factor and tumor suppressor very frequently mutated in human cancer and often termed “guardian of the genome”. Activated by DNA damage, oxidative stress, or deregulated oncogene expression, p53 binds to a specific site in the promoter region of target genes and leads to the transcriptional activation of downstream genes involved in DNA repair, cell cycle arrest, senescence, and apoptosis. Inactivation of p53 promotes genome instability and directly contributes to cell transformation.
2. Ryan, K.M., et al., Curr. Opin. Cell Biol. 13(3): 332-337.
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