ERK1 Recombinant

Catalog #
40055
$410 *
Size: 10 µg
Qty
*US Pricing only. For international pricing, please contact your local distributor.
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Synonyms
MAPK3, PRKM3, P44ERK1, P44MAPK, HS44 kDaP, HUMKER1A, MGC20180, ERK-1
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
E. coli
Purity
≥90%
Format
Aqueous buffer solution
Formulation

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

MW
44 kDa
Amino Acids
1-379(end)
Specific Activity

375 pmol/min/µg

Genbank #
NM_002746
UniProt #
P27361
Tag(s)
none
Background
ERK1 is a protein serine/threonine kinase that is a member of the extracellular signal-regulated kinases (ERKs) which are activated in response to numerous growth factors and cytokines (1). Activation of ERK1 requires both tyrosine and threonine phosphorylation that is mediated by MEK. ERK1 is ubiquitously distributed in tissues with the highest expression in heart, brain and spinal cord. Activated ERK1 translocates into the nucleus where it phosphorylates various transcription factors (e.g., Elk-1, c-Myc, c-Jun, c-Fos, and C/EBP beta).
References
Boulton, TG. et al. Biochemistry. 1991 Jan 8,30(1):278-86.