p53, FLAG-Tag Recombinant

Catalog #

100412

$325 *

Size: 20 µg

Qty

Bulk/Custom

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Description

Recombinant human p53 (cellular tumor antigen p53), encompassing amino acids 2-394(end). This construct contains an N-terminal FLAG-tag followed by a Precission cleavage site. This protein was affinity purified.

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Synonyms

cellular tumor antigen p53, tumor suppressor p53, TP53, p53

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Product Data Gallery

4-20% SDS-PAGE Coomassie Staining

Product Info

Storage and Usage

Citations

Species

Human

Construct

p53 (FLAG-2-394(end))

Host Species/Expression System

E. coli

Purity

≥90%

Format

Aqueous buffer solution.

Formulation

40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, 20% glycerol, 3 mM DTT, and variable FLAG peptide

46 kDa

Amino Acids

2-394(end)

Genbank #

NM_000546

UniProt #

P04637

Tag(s)

N-terminal FLAG-Tag

Background

p53 is a transcription factor and tumor suppressor very frequently mutated in human cancer and often termed “guardian of the genome”. Activated by DNA damage, oxidative stress, or deregulated oncogene expression, p53 binds to a specific site in the promoter region of target genes and leads to the transcriptional activation of downstream genes involved in DNA repair, cell cycle arrest, senescence, and apoptosis. Inactivation of p53 promotes genome instability and directly contributes to cell transformation.

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Datasheets/Protocols

100412 Lot 190806

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p53, FLAG-Tag Recombinant

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