EGFR (del746-750, T790M, C797S), GST-Tag, His-Tag Recombinant
Recombinant human EGFR (epidermal growth factor receptor) encompassing tyrosine kinase domain amino acids 668-1210(end) with a deletion of amino acids 746 to 750 and mutations T790M and C797S. This construct contains an N-terminal GST-tag and a C-terminal His-tag (6xHis). This protein was affinity purified.
≥65%
Aqueous buffer solution.
40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, 20% glycerol, and 3 mM DTT
EFGR (epidermal growth factor receptor), also known as ErbB-1 and HER1, is the cell-surface receptor for members of the epidermal growth factor family, such as TGFα (transforming growth factor alpha) and belongs to the ErbB family of receptors. Overexpression and/or hyperactivation of EGFR is associated with several human cancers such as lung, glioblastoma, and epithelial tumors of the neck and head, whereas EGFR deficiency is linked to Alzheimer’s. After binding to its ligand, EGFR dimerizes and undergoes auto-phosphorylation, resulting in activation of signal transduction cascades that involve proteins such as JNK (c-jun N-terminal kinases) and AKT (protein kinase B). Its role as an oncogene has led to the development of inhibitors as cancer therapy.
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