EGFR (T790M, C797S) (del746-750) Kinase Assay Kit
The EGFR (T790M, C797S) (del746-750) Kinase Assay Kit is designed to measure the kinase activity of mutant EGFR (T790M, C797S) (del746-750) for screening and profiling applications using Kinase-Glo™ Max as a detection reagent. The assay kit comes in a convenient 96-well format, with enough purified recombinant EGFR (T790M, C797S) (del746-750) kinase, kinase substrate, ATP and kinase assay buffer for 100 enzyme reactions.
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- Kinase-Glo MAX Kinase Assay
- Microplate reader capable of reading luminescence
- Adjustable micropipettor and sterile tips
- 30°C incubator
| Catalog # | Name | Amount | Storage |
| 100187 | EGFR (T790M, C797S) (del746-750)* | 2 µg | -80°C |
| 79334 | 5X Kinase Assay Buffer 1 | 1.5 ml | -20°C |
| 79686 | ATP (500 µM) | 100 µl | -20°C |
| 40217 | PTK substrate Poly (Glu:Tyr: 4:1) (10 mg/ml) | 100 µl | -20°C |
| 79696 | 96-well plate, white | 1 | Room Temp. |
*The concentration of the protein is lot-specific and will be indicated on the tube
The EGFR (epidermal growth factor receptor), also known as ErbB-1 and HER1, is a cell surface tyrosine kinase receptor belonging to the epidermal growth factor receptor family. Overexpression and/or hyperactivation of EGFR kinase is associated with several human cancers such as lung, glioblastoma, and epithelial tumors of the neck and head. This increased activity of EGFR has led to the development of anticancer therapeutics targeting EGFR. However, d746-750, T790M, and C797S mutations in EGFR can cause resistance to known EGFR inhibitors, requiring the development of next generation mutant-selective inhibitors.
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