CD8a, Fc Fusion, Avi-Tag, Biotin-Labeled, HiP™ Recombinant

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Catalog #

101871

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Description

Recombinant human CD8a (cluster of differentiation 8 a) transcript 1 encompassing amino acids 22-182. This construct contains a C-terminal Fc domain followed by an Avi-Tag™. The recombinant protein was affinity purified. HiP™ indicates a high purity protein (≥90% pure) with less than 10% aggregation as measured by gel filtration.

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Synonyms

T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2, CD8a, CD8A, MAL

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Product Data Gallery

4-20% SDS-PAGE Coomassie Staining

Biotin-Avidin Pulldown

Gel Filtration Curve

Product Info

Storage and Usage

Citations

Species

Human

Construct

CD8a (22-182-Fc(lgG1)-Avi)-(Biotin)

Host Species/Expression System

HEK293

Purity

≥90%

Format

Aqueous buffer solution

Formulation

8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol

47 kDa + glycans

Amino Acids

22-182

Glycosylation

This protein runs at a higher MW by SDS-PAGE due to glycosylation.

Aggregation

<10%

Genbank #

NM_001768.7

UniProt #

P01732

Tag(s)

C-terminal Avi-Tag™

Label

This protein is enzymatically biotinylated using Avi-Tag™ technology. Biotinylation was confirmed to be ≥90%.

For more information on enzymatic biotinylation, please see our Tech Note.

Background

CD8 is a co-receptor for the TCR (T cell receptor) in T cells, binding to MHC (major histocompatibility complex) class I proteins. CD8 is a typical marker of cytotoxic T cells and is involved in signaling. CD8 has two isoforms, a and b. CD8b recruits Lck (lymphocyte-specific protein tyrosine kinase) to the TCR-CD3 complex, and Lck phosphorylates multiple proteins involved in activation of cytotoxic T lymphocytes. It is thus critical for the lysis of cancer cells.

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Datasheets/Protocols

101871 Lot 230713

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CD8a, Fc Fusion, Avi-Tag, Biotin-Labeled, HiP™ Recombinant

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