CD8a, Fc Fusion, Avi-Tag, HiP™ Recombinant
Recombinant human CD8a (cluster of differentiation 8 a) transcript 1 encompassing amino acids 22-182. This construct contains a C-terminal Fc domain followed by an Avi-Tag™. The recombinant protein was affinity purified. HiP™ indicates a high purity protein (≥90% pure) with less than 10% aggregation as measured by gel filtration.
≥90%
Aqueous buffer solution
8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
CD8 is a co-receptor for the TCR (T cell receptor) in T cells, binding to MHC (major histocompatibility complex) class I proteins. CD8 is a typical marker of cytotoxic T cells and is involved in signaling. CD8 has two isoforms, a and b. CD8b recruits Lck (lymphocyte-specific protein tyrosine kinase) to the TCR-CD3 complex, and Lck phosphorylates multiple proteins involved in activation of cytotoxic T lymphocytes. It is thus critical for the lysis of cancer cells.