CD8a, Avi-Tag, His-Tag, Biotin-Labeled Recombinant
Recombinant human CD8a (cluster of differentiation 8 a) transcript 1 encompassing amino acids 22-182. This construct contains a C-terminal Avi-Tag™ followed by a His-Tag (6xHis). This protein was affinity purified.
≥90%
Aqueous buffer solution.
8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
This protein is enzymatically biotinylated using Avi-Tag™ technology. Biotinylation was confirmed to be ≥90%.
For more information on enzymatic biotinylation, please see our Tech Note.
CD8 is a co-receptor for the TCR (T cell receptor) in T cells, binding to MHC (major histocompatibility complex) class I proteins. CD8 is a typical marker of cytotoxic T cells and is involved in signaling. CD8 has two isoforms, a and b. CD8b recruits Lck (lymphocyte-specific protein tyrosine kinase) to the TCR-CD3 complex, and Lck phosphorylates multiple proteins involved in activation of cytotoxic T-lymphocytes. It is thus critical for the lysis of cancer cells.
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