3-aminobenzamide

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Catalog #

79888

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Description

3-aminobenzamidine is a novel, potent inhibitor of PARP. 3-Aminobenzamide enhances apoptosis by interrupting the rejoining of DNA strand breaks induced by both ionizing radiations or alkylating agents. It also exhibits protective action against myocardial reperfusion injury and local inflammation.

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Synonyms

3-AB, 3-Carboxamidoaniline

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Product Info

Storage and Usage

Citations

Purity

≥98% by HPLC

Formula

C₇H₈N₂O

136.2 Da

Solubility

Soluble in DMSO (30 mg/ml) and water (25 mg/ml)

Biological Activity

3-aminobenzamide is a PARP inhibitor with an IC50 of ~30 µM.

CAS Registry #

3544-24-9

Background

3-Aminobenzamide stimulates unscheduled DNA synthesis and rejoining of strand breaks in human lymphocytes

References

1. Ferraris D.V., J of Med Chem, 2010, 53, 4561-4584

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3-aminobenzamide

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