Kinase(s)

 

Protein phosphorylation is a key aspect in the regulation of a large number of cellular processes including cellular division, metabolism, signal transduction, and many more. There are over 500 kinases encoded by the human genome and it has been estimated that kinases regulate approximately 50% of cellular functions. Kinase is the name given to an enzyme that catalyzes the transfer of a phosphate group from ATP to another molecule. Kinases can be broadly separated by their substrate into protein and lipid kinases with the protein kinases being further classified based on their cellular location and the specific amino acid(s) they phosphorylate; cytoplasmic threonine, receptor tyrosine kinases (RTKs), and serine/threonine.

The prominent roles that kinases play in cell division have made them attractive targets for both immunosuppressant drugs and cancer therapeutics. Kinases are highly druggable, and account for over 25% of targets screened by the pharmaceutical industry. Currently, there are over 25 kinase inhibitors that have been approved for clinical use by the FDA, including rapamycin, which was discovered in the 1960s. It was not until three decades later, however, that the target of rapamycin was discovered to be a serine/threonine kinase that was named mammalian target of rapamycin (mTOR). Today rapamycin is approved as an immunosuppressant and a number of mTOR inhibitors are being investigated as treatments for various forms of cancer.

BPS offers a wide selection of kinases, kinase substrates and kinase inhibitors. Our kinases are validated through rigorous QC testing and are suitable for use in nearly all in vitro kinase assays. We also offer kinase inhibitor screening services.

References:

1.   Cohen, P. Nat. Rev. Drug Disc. 2002; 1: 309-315.
2.   Ballou, L.M., et al., J. Chem. Biol. 2008 1(1-4): 27-36.
3.   Loewith, R., et al., Genetics. 2011; 189(4): 1177-1201.

 

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Catalog#SizeProduct NamePrice
40646 10 µg PI3 Kinase [p110α (N345K)/p85α], His-Tag
$370
79023 20 μg 14-3-3 alpha/beta Protein, His-tag (Human)
$220
79024 20 μg 14-3-3 alpha/beta Protein, His-tag (Mouse)
$220
79025 20 μg 14-3-3 epsilon Protein, His-tag (Human)
$220
79026 20 μg 14-3-3 epsilon Protein, His-tag (Mouse)
$220
79037 20 μg 14-3-3 sigma Protein, His-tag (Human)
$355
79038 20 μg 14-3-3 theta Protein, His-tag (Human)
$355
79039 20 μg 14-3-3 zeta Protein, His-tag (Human)
$355
79040 20 μg 14-3-3 zeta Protein, His-tag (Mouse)
$355
27057 5 mg A-769662
$75
40415 10 µg Abl Kinase Mutant (T334I), His-tag
$345
40411 10 µg Abl Kinase, His-tag
$345
40417 10 µg ABL2, His-tag
$370
40400 10 µg ACK1, GST-tag
$345
27009 10 mg Afatinib
$220
40000 100 µg AKT1, Inactive, His-tag
$345
40214 10 µg ALK , GST-tag
$345
40018 10 µg ALK1, GST-tag
$370
40019 10 µg ALK2, GST-tag
$370
40020 10 µg ALK4, GST-tag
$370
27058 25 mg Alvocidib
$225
40025 10 µg AMPK (A1/B1/G1), His-tags
$595
40701 5 µg AMPK (A1/B1/G2), His-tag
$470
40021 10 µg AMPK (A1/B1/G2), His-tags
$595
40702 5 µg AMPK (A1/B1/G3), His-tag
$470

Items 1 to 25 of 437 total

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