Kinase(s)

 

Protein phosphorylation is a key aspect in the regulation of a large number of cellular processes including cellular division, metabolism, signal transduction, and many more. There are over 500 kinases encoded by the human genome and it has been estimated that kinases regulate approximately 50% of cellular functions. Kinase is the name given to an enzyme that catalyzes the transfer of a phosphate group from ATP to another molecule. Kinases can be broadly separated by their substrate into protein and lipid kinases with the protein kinases being further classified based on their cellular location and the specific amino acid(s) they phosphorylate; cytoplasmic threonine, receptor tyrosine kinases (RTKs), and serine/threonine.

The prominent roles that kinases play in cell division have made them attractive targets for both immunosuppressant drugs and cancer therapeutics. Kinases are highly druggable, and account for over 25% of targets screened by the pharmaceutical industry. Currently, there are over 25 kinase inhibitors that have been approved for clinical use by the FDA, including rapamycin, which was discovered in the 1960s. It was not until three decades later, however, that the target of rapamycin was discovered to be a serine/threonine kinase that was named mammalian target of rapamycin (mTOR). Today rapamycin is approved as an immunosuppressant and a number of mTOR inhibitors are being investigated as treatments for various forms of cancer.

BPS offers a wide selection of kinases, kinase substrates and kinase inhibitors. Our kinases are validated through rigorous QC testing and are suitable for use in nearly all in vitro kinase assays. We also offer kinase inhibitor screening services.

References:

1.   Cohen, P. Nat. Rev. Drug Disc. 2002; 1: 309-315.
2.   Ballou, L.M., et al., J. Chem. Biol. 2008 1(1-4): 27-36.
3.   Loewith, R., et al., Genetics. 2011; 189(4): 1177-1201.

 

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Catalog#SizeProduct NamePrice
40646 10 µg PI3 Kinase [p110α (N345K)/p85α], His-Tag
$365
79023 20 μg 14-3-3 alpha/beta Protein, His-tag (Human)
$215
79024 20 μg 14-3-3 alpha/beta Protein, His-tag (Mouse)
$215
79025 20 μg 14-3-3 epsilon Protein, His-tag (Human)
$215
79026 20 μg 14-3-3 epsilon Protein, His-tag (Mouse)
$215
79029 20 μg 14-3-3 eta Protein (Human)
$215
79030 20 μg 14-3-3 eta Protein, GST-tag (Human)
$215
79031 20 μg 14-3-3 eta Protein, GST-tag (Human)
$215
79027 20 μg 14-3-3 eta Protein, His-tag (Human)
$215
79028 20 μg 14-3-3 eta Protein, His-tag (Mouse)
$215
79034 20 μg 14-3-3 gamma Protein (Human)
$350
79035 20 μg 14-3-3 gamma Protein, GST-tag
$280
79036 20 μg 14-3-3 gamma Protein, GST-tag
$280
79033 20 μg 14-3-3 gamma Protein, His-tag (Human)
$350
79032 20 μg 14-3-3 gamma Protein, His-tag (Mouse)
$215
79037 20 μg 14-3-3 sigma Protein, His-tag (Human)
$350
79038 20 μg 14-3-3 theta Protein, His-tag (Human)
$350
79039 20 μg 14-3-3 zeta Protein, His-tag (Human)
$350
79040 20 μg 14-3-3 zeta Protein, His-tag (Mouse)
$350
27057 5 mg A-769662
$75
40415 10 µg Abl Kinase Mutant (T334I), His-tag
$345
40411 10 µg Abl Kinase, His-tag
$345
40417 10 µg ABL2, His-tag
$365
40400 10 µg ACK1, GST-tag
$345
27009 10 mg Afatinib
$215

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