Dicer, FLAG-Tag Recombinant

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Catalog #

101532

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Description

Recombinant human Dicer (Endoribonuclease Dicer), full length, encompassing amino acids 2-1922(end). This construct contains an N-terminal Flag-tag. The recombinant protein was affinity purified.

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Synonyms

Endoribonuclease Dicer, Helicase with RNase motif (Helicase MOI), DICER1, DICER, HERNA, KIAA0928

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Product Data Gallery

4-20% SDS-PAGE Coomassie Staining

Product Info

Storage and Usage

Citations

Species

Human

Construct

Dicer (FLAG-2-1922(end))

Host Species/Expression System

Sf9

Purity

≥85%

Format

Aqueous buffer solution

Formulation

40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol

220 kDa

Amino Acids

2-1922(end)

Genbank #

NM_030621

UniProt #

Q9UPY3

Tag(s)

N-terminal FLAG-tag

Background

Dicer (also known as endoribonuclease Dicer or helicase with RNase motif) is a ribonuclease that participates in pre-microRNA (pre-miRNA) and double stranded RNA (dsRNA) cleavage. The cleavage of pre-miRNA into mature miRNA and formation of small interfering RNA (siRNA) from dsRNA are essential for gene regulation and DNA repair. Decreased levels of Dicer can result in Age-related Macular Degeneration (AMD), the most common age-related blindness. Dicer impairment is also involved in cancer and RNA-based viral infection. The development of small molecule inhibitors or other strategies that affect Dicer activity can provide new therapeutical avenues for cancer treatment and AMD prevention.

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Datasheets/Protocols

101532 Lot 221019

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