Cell Surface Receptor(s)

 

Cell surface receptors, often called transmembrane receptors, are important proteins that mediate communication between the cell and the outside world. Extracellular ligands (cytokines, growth factors, hormones, neurotransmitters, or cell recognition molecules) bind to the receptor, triggering conformational changes that initiate intracellular signaling pathways (signal transduction). Cell surface receptors regulate a multitude of biological pathways required for cell growth, differentiation, proliferation, and survival.

Because of the critical nature of these pathways, it is not surprising that mutations in cell surface receptors are responsible for a wide array of diseases, including cancers, neurodegeneration, achondroplasia and atherosclerosis. In fact, nearly half of all drugs in clinical use target cell surface receptors, and these proteins and their ligands remain extremely important targets for structure-based drug design and novel drug development.

Cell Surface Receptors are divided into 3 major classes: ion channel-linked receptors, enzyme-linked receptors, and G protein-coupled receptors.

Ion channels are pore-forming proteins present in the membranes of all cells. Ions pass through channels down their electrochemical gradient, without the requirement for ATP or metabolic energy. Ion channels are especially prominent components of the nervous system, since "transmitter-activated" channels mediate conduction across nerve synapses. Ion channels are also key components in the cellular response to toxins and venoms, as well as biological processes that involve rapid changes in cells, such as cardiac, skeletal, and smooth muscle contraction, T-cell activation and hormone release.

Enzyme-linked receptors are usually single-pass transmembrane receptors. This group includes the highly studied receptor tyrosine kinases (RTKs), which bind to polypeptide growth factors that control cell proliferation and differentiation. Also included are receptor serine/threonine kinases, receptor-like tyrosine phosphatases, and receptor guanylyl cyclases that catalyze the production of cyclic GMP in the cytosol.

G-protein-coupled receptors (GPCRs), also known as 7 transmembrane (7-TM) receptors, are structurally and functionally related proteins characterized by seven membrane-spanning a helices. GPCRs are involved in numerous signaling pathways, including sensory perception (sight, smell, taste, pain). GPCRs are also activated by many neurotransmitters, neuropeptides, and peptide hormones.

Our portfolio of cell surface receptor products includes antibodies, assay kits, cell lines for GPCRs and ion channels, and purified soluble receptors.

References:

1.  Overington, J.P., et al., Nat. Rev. Drug Disc. 2006; 5: 993-996.
2.  Sallman, M. et al., BMC Biol. 2009; 7: 50. 

 

Cell Surface Receptor Subcategories

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Catalog#SizeProduct NamePrice
72306 50 μg CD244, Fc Fusion (IgG1), Biotin-Labeled (Human)
$420
79107 50 μg CD27(Mouse), Fc-Fusion (Human), Avi-Tag, Biotin
$420
71176 100 µg CD27, Fc fusion (Human)
$310
79067 100 μg CD27, Fc-Fusion (IgG1), Avi-Tag (Mouse) HiP™
$310
79337 100 μg CD276, Avi-His-Tag HiP™
$310
79367 50 μg CD276, Avi-His-Tag, Biotin-Labeled HiP™
$405
71113 200 µg CD28, Fc fusion (Human)
$310
72007 96 reactions CD28:B7-1[Biotinylated] Inhibitor Screening Assay Kit
$1,040
72062 96 reactions CD28:B7-2[Biotinylated] Inhibitor Screening Assay Kit
$1,040
72511 50 μg CD30, Fc-Fusion (IgG1), Avi-Tag, Biotin-Labeled
$420
71174 100 µg CD40, Fc fusion (Human)
$310
71187 100 µg CD44, Fc fusion (Human)
$310
71133 50 µg CD44, Fc fusion, Biotin-labeled (Human) HiP™
$420
71232 100 µg CD46-BC, His-tag (Monkey)
$310
71231 100 µg CD46-C, His-tag (Human)
$310
71233 100 µg CD46-C, His-tag (Monkey)
$310
79118 100 μg CD47 (Monkey), Fc Fusion (Human), Avi-Tag HiP™
$310
79302 50 μg CD47 (Monkey), Fc Fusion (Human), Avi-Tag, Biotin HiP™
$420
71177 100 µg CD47, Fc fusion (Human) HiP™
$315
72514 50 μg CD47, Fc Fusion, Avi-Tag, Biotin-Labeled (Mouse)
$420
71169 50 μg CD47, Fc fusion, Biotin-labeled (Human) HiP™
$420
71292 100 µg CD47, Fc-Fusion, Streptavidin-Labeled (Human) HiP™
$310
71127 100 µg CD47, His-tag (Human)
$315
72059 96 reactions CD47:SIRP-γ[Biotinylated] Inhibitor Screening Assay Kit
$1,040
72309 100 μg CD48, Fc fusion (IgG1), Avi-Tag™ HiP™ (Human)
$320

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