Cell Surface Receptor(s)

 

Cell surface receptors, often called transmembrane receptors, are important proteins that mediate communication between the cell and the outside world. Extracellular ligands (cytokines, growth factors, hormones, neurotransmitters, or cell recognition molecules) bind to the receptor, triggering conformational changes that initiate intracellular signaling pathways (signal transduction). Cell surface receptors regulate a multitude of biological pathways required for cell growth, differentiation, proliferation, and survival.

Because of the critical nature of these pathways, it is not surprising that mutations in cell surface receptors are responsible for a wide array of diseases, including cancers, neurodegeneration, achondroplasia and atherosclerosis. In fact, nearly half of all drugs in clinical use target cell surface receptors, and these proteins and their ligands remain extremely important targets for structure-based drug design and novel drug development.

Cell Surface Receptors are divided into 3 major classes: ion channel-linked receptors, enzyme-linked receptors, and G protein-coupled receptors.

Ion channels are pore-forming proteins present in the membranes of all cells. Ions pass through channels down their electrochemical gradient, without the requirement for ATP or metabolic energy. Ion channels are especially prominent components of the nervous system, since "transmitter-activated" channels mediate conduction across nerve synapses. Ion channels are also key components in the cellular response to toxins and venoms, as well as biological processes that involve rapid changes in cells, such as cardiac, skeletal, and smooth muscle contraction, T-cell activation and hormone release.

Enzyme-linked receptors are usually single-pass transmembrane receptors. This group includes the highly studied receptor tyrosine kinases (RTKs), which bind to polypeptide growth factors that control cell proliferation and differentiation. Also included are receptor serine/threonine kinases, receptor-like tyrosine phosphatases, and receptor guanylyl cyclases that catalyze the production of cyclic GMP in the cytosol.

G-protein-coupled receptors (GPCRs), also known as 7 transmembrane (7-TM) receptors, are structurally and functionally related proteins characterized by seven membrane-spanning a helices. GPCRs are involved in numerous signaling pathways, including sensory perception (sight, smell, taste, pain). GPCRs are also activated by many neurotransmitters, neuropeptides, and peptide hormones.

Our portfolio of cell surface receptor products includes antibodies, assay kits, cell lines for GPCRs and ion channels, and purified soluble receptors.

References:

1.  Overington, J.P., et al., Nat. Rev. Drug Disc. 2006; 5: 993-996.
2.  Sallman, M. et al., BMC Biol. 2009; 7: 50. 

 

Cell Surface Receptor Subcategories

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Catalog#SizeProduct NamePrice
71197 100 μg CD112, His-tag (Human) HiP™
$310
71234 50 μg CD112, His-tag, Biotin-labeled (Human) HiP™
$420
72510 100 μg CD113, Fc-Fusion (IgG1), Avi-Tag
$310
71170 100 µg CD137 (4-1BB), Fc fusion (Human) HiP™
$300
71171 50 µg CD137 (4-1BB), Fc Fusion, Biotin-labeled (Human) HiP™
$405
71250 100 μg CD137, Fc fusion (hIgG1) (Mouse)
$310
71254 100 µg CD137, Fc fusion (mIgG2a), Avi-tag (Mouse) HiP™
$310
71255 50 µg CD137, Fc fusion (mIgG2a), Biotin-labeled (Mouse) HiP™
$420
71189 100 µg CD137L (4-1BB ligand), His-tag
$310
72517 100 µg CD137L, His-Tag (Mouse)
$310
72025 96 reactions CD137[Biotinylated]:CD137L Inhibitor Screening Assay Kit
$995
72307 50 μg CD150, Fc Fusion (IgG1), Biotin Labeled (Human)
$420
72304 100 μg CD150, Fc Fusion, Avi-Tag (Human)
$320
71181 100 µg CD155 (PVR), His-tag (Human)
$315
71181-2 1 mg CD155 (PVR), His-tag (Human)
$2,835
71173 100 µg CD160, His-tag (Human) HiP™
$310
71135 50 µg CD160, His-tag, Biotin-labeled (Human) HiP™
$420
71264 100 μg CD2, Fc fusion, Avi-Tag, (Human) HiP™
$320
71270 50 µg CD2, Fc fusion, Biotin-labeled (Human) HiP™
$420
71252 100 µg CD226, Fc fusion (Human) HiP™
$310
71253 50 µg CD226, Fc fusion, Biotin-labeled (Human) HiP™
$420
72051 384 reactions CD226:CD112 Homogeneous Assay Kit
$325
72052 384 reactions CD226:CD155 Homogeneous Assay Kit
$325
72305 100 μg CD244, Fc Fusion (IgG1), Avi-Tag (Human)
$320
72306 50 μg CD244, Fc Fusion (IgG1), Biotin-Labeled (Human)
$420

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