Cell Surface Receptor(s)

 

Cell surface receptors, often called transmembrane receptors, are important proteins that mediate communication between the cell and the outside world. Extracellular ligands (cytokines, growth factors, hormones, neurotransmitters, or cell recognition molecules) bind to the receptor, triggering conformational changes that initiate intracellular signaling pathways (signal transduction). Cell surface receptors regulate a multitude of biological pathways required for cell growth, differentiation, proliferation, and survival.

Because of the critical nature of these pathways, it is not surprising that mutations in cell surface receptors are responsible for a wide array of diseases, including cancers, neurodegeneration, achondroplasia and atherosclerosis. In fact, nearly half of all drugs in clinical use target cell surface receptors, and these proteins and their ligands remain extremely important targets for structure-based drug design and novel drug development.

Cell Surface Receptors are divided into 3 major classes: ion channel-linked receptors, enzyme-linked receptors, and G protein-coupled receptors.

Ion channels are pore-forming proteins present in the membranes of all cells. Ions pass through channels down their electrochemical gradient, without the requirement for ATP or metabolic energy. Ion channels are especially prominent components of the nervous system, since "transmitter-activated" channels mediate conduction across nerve synapses. Ion channels are also key components in the cellular response to toxins and venoms, as well as biological processes that involve rapid changes in cells, such as cardiac, skeletal, and smooth muscle contraction, T-cell activation and hormone release.

Enzyme-linked receptors are usually single-pass transmembrane receptors. This group includes the highly studied receptor tyrosine kinases (RTKs), which bind to polypeptide growth factors that control cell proliferation and differentiation. Also included are receptor serine/threonine kinases, receptor-like tyrosine phosphatases, and receptor guanylyl cyclases that catalyze the production of cyclic GMP in the cytosol.

G-protein-coupled receptors (GPCRs), also known as 7 transmembrane (7-TM) receptors, are structurally and functionally related proteins characterized by seven membrane-spanning a helices. GPCRs are involved in numerous signaling pathways, including sensory perception (sight, smell, taste, pain). GPCRs are also activated by many neurotransmitters, neuropeptides, and peptide hormones.

Our portfolio of cell surface receptor products includes antibodies, assay kits, cell lines for GPCRs and ion channels, and purified soluble receptors.

References:

1.  Overington, J.P., et al., Nat. Rev. Drug Disc. 2006; 5: 993-996.
2.  Sallman, M. et al., BMC Biol. 2009; 7: 50. 

 

Cell Surface Receptor Subcategories

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Catalog#SizeProduct NamePrice
71209 100 µg Anti-CD20 Antibody
$300
71212 100 µg Anti-CTLA4 Neutralizing Antibody
$445
71207 50 µg Anti-PCSK9 Neutralizing Antibody
$455
71216 50 µg Anti-PCSK9 Neutralizing Antibody, Biotin-labeled
$500
71326 100 µg Anti-PD-1 (S228P) Antibody
$445
71120 100 µg Anti-PD-1 Neutralizing Antibody
$445
71215 100 µg Anti-PD-1 Neutralizing Antibody, Biotin-labeled
$465
71213 100 µg Anti-PD-L1 (CD274) Neutralizing Antibody
$445
71214 100 µg Anti-PD-L1 Neutralizing Antibody, Biotin-labeled
$465
71223 100 µg Anti-β-Amyloid, Plaque Neutralizing Antibody
$445
71125 100 µg B7-1 (CD80), Fc fusion (Human) HiP™
$300
71114 50 µg B7-1 (CD80), Fc fusion, Biotin-labeled (Human) HiP™
$405
71150 100 µg B7-2 (CD86), Fc fusion (Human)
$300
71159 50 μg B7-2 (CD86), Fc fusion, Biotin labeled (Human) HiP™
$405
71144 100 µg B7-H4, His-tag (Human)
$300
71129 50 µg B7-H4, His-tag, Biotin-labeled (Human) HiP™
$405
71148 100 µg B7-H5 (VISTA), Fc fusion (Human) HiP™
$300
71327 50 µg B7-H5 Fc fusion, Avi-Tag, Biotin-labeled (Human)
$405
71141 100 µg BTLA(CD272), Fc fusion (Human)
$300
72008 96 reactions BTLA:HVEM[Biotinylated] Inhibitor Screening Assay Kit
$995
72231 50 μg CD112, Fc-Fusion, Avi-Tag, Biotin-labeled (Human)
$405
71197 100 μg CD112, His-tag (Human) HiP™
$300
71234 50 μg CD112, His-tag, Biotin-labeled (Human) HiP™
$405
71170 100 µg CD137 (4-1BB), Fc fusion (Human) HiP™
$300
71171 50 µg CD137 (4-1BB), Fc Fusion, Biotin-labeled (Human) HiP™
$405

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