VEGFR2 (KDR), Avi-Tag, His-Tag, Biotin-Labeled Recombinant
Recombinant human VEFGR2 (vascular endothelial growth factor receptor 2), also known as kinase insert domain receptor (KDR), encompassing amino acids 20-764 corresponding to the extracellular domain of the receptor. This construct contains a C-terminal Avi-Tag™ followed by an His-tag (6xHis). This protein was affinity purified.
≥90%
Aqueous buffer solution.
8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
This protein is enzymatically biotinylated using Avi-Tag™ technology. Biotinylation is confirmed to be ≥90%.
For more information on enzymatic biotinylation, please see our Tech Note.
The interaction between VEGF (Vascular Endothelial Growth Factor) and its receptor VEGFR is an important mediator of angiogenesis as well as endothelial cell survival and proliferation. VEGFR2 is a receptor tyrosine kinase that plays a major role in cellular responses driven by VEGF. Targeting the kinase activity of VEGFR2 has been an attractive tool in cancer therapy based on its anti-angiogenesis effects. In addition to the kinase inhibitors, humanized monoclonal antibodies interfering with VEGF/VEGFR2 interaction have been developed as anti-cancer treatments.
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