Suberohydroxamic Acid (SBHA)

Catalog #

27210

$110 *

Size: 100 mg

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Bulk/Custom

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Description

Suberohydroxamic acid (SBHA) is a competitive HDAC inhibitor. SBHA has been shown to cause cell differentiation, cell cycle arrest, and apoptosis.

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Product Info

Storage and Usage

Citations

Purity

≥98% by HPLC

Format

A crystalline solid

Formula

C₈H₁₆N₂O₄

204.2 Da

Solubility

Soluble in DMSO and DMF, purged with an inert gas. Solubility in DMSO and DMF is approximately 1.3 mg/ml and 0.1 mg/ml respectively. For maximum solubility in aqueous buffers, dissolve SBHA in DMSO then dilute with the aqueous buffer of choice.

Biological Activity

SBHA inhibits HDAC1 with an IC50 = 0.25 µM and HDAC3 with an IC50 = 0.3 µM.

CAS Registry #

38937-66-5

References

1. Richon, VM, et al., Proc. Natl. Acad. Sci USA. 1998; 95: 3003-3007.
2. Brinkmann, H., et al., J. Biol. Chem. 2001; 276(25): 22491-22499.
3. Ning, L, et al., Oncologist. 2008; 13: 98-104.

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Suberohydroxamic Acid (SBHA)

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