Parthenolide

Catalog #

27768-1

$240 *

Size: 250 mg

Qty

Bulk/Custom

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Description

Parthenolide specifically inhibits HDAC1 without affecting other class I/II HDACs.

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Synonyms

(1aR,7aS,10aS,10bS,E)-1a,5-dimethyl-8-methylene-2,3,6,7,7a,8,10a,10b-octahydrooxireno[2',3':9,10]cyclodeca[1,2-b]furan-9(1aH)-one

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Product Data Gallery

Product Info

Storage and Usage

Citations

Format

white to off-white crystalline solid.

Target(s)

HDAC1

Formula

C₁₅H₂₀O₃

248.3 Da

Solubility

Soluble in DMSO (100 mg/ml) or 100% ethanol (20 mg/ml).

CAS Registry #

20554-84-1

Background

Parthenolide is a sesquiterpene lactone, a class of naturally occurring plant terpenoids, and the active principle of feverfew (Chrysanthemum parthenium). Parthenolide has demonstrated anti-inflammatory, antisecretory and spasmolytic activity. Parthenolide has been shown to inhibit the release of various chemical mediators such as Cox-2, TNF-α and IL-1 in LPS-stimulated macrophages and activation of MAP kinase and NFκβ. Recent findings indicate that parthenolide binds to and directly inhibits Iκβ kinase. The compound has also been shown to block the production of thromboxane B2 and leukotriene B4.

References

1. Gopal, Y.N.V., et al. 2007. Chemistry and Biology 14(7) 813-823.
2. Groenewegen, W.A., et al. 1990. J. Pharm. Pharmacol. 42: 553-557.
3. 2. Sumner, H., et al. 1992. Biochem. Pharmacol. 43: 2313-2320.
4. 3. Barsby, R.W., et al. 1992. J. Pharm. Pharmacol. 44 :737-740.

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