Mocetinostat (MGCD0103)

Catalog #

27109

$380 *

Size: 5 mg

Qty

Bulk/Custom

Add to Favorites

*US Pricing only. For international pricing, please contact your local distributor.

●

Purchase

●

Description

Mocetinostat (MGCD0103) is an HDAC inhibitor. It was shown to induce hyperacetylation of histones resulting in cancer cell selective apoptosis, and cause cell cycle blockade in various human cancer cell lines in a dose-dependent manner. Mocetinostat inhibites growth of human tumor xenografts in nude mice in a dose-dependent manner and its antitumor activity correlates with induction of histone acetylation in tumors.

●

Synonyms

MGCD0103

Product Info

Storage and Usage

Citations

Purity

≥99% by HPLC

Format

A crystalline solid

Formula

C₂₃H₂₀N₆O

396.4 Da

Solubility

Solubility in DMSO is 13 mg/ml, and in water and ethanol is < 1 mg/ml. DMSO stock solutions are stable up to one week at 4ºC or up to a month at -70ºC. Do not store aqueous solutions for more than one day.

Biological Activity

Mocetinostat (MGCD0103) inhibits HDAC1, HDAC2 and HDAC3 with IC50 values of 0.15 µM, 0.29 µM and 1.66 µM, respectively.

CAS Registry #

726169-73-9

References

1. Foumel, M., et al., Mol Cancer Ther. 2008;7:759-768.
2. Duque-Afonso, J., et al. Oncogene 2011. July;30:3062-72.
3. Munkacsi, A.B., et al. J. Biol. Chem. 2011. July;286:23842-51.
4. Xu, X., et al. PLoS ONE. February 2011. 6:e17138.

Skip to the end of the images gallery

Skip to the beginning of the images gallery

Mocetinostat (MGCD0103)

PRODUCTS

SERVICES

RESOURCES

COMPANY