RGFP966

Catalog #

27643-2

$245 *

Size: 25 mg

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Description

RGFP966 is specific for HDAC3, with an IC50 of 0.08 µM and no effective inhibition of any other HDAC at concentrations up to 15 µM.

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Synonyms

(E)-N-(2-amino-4-fluorophenyl)-3-(1-cinnamyl-1H-pyrazol-4-yl)acrylamide

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Product Data Gallery

Product Info

Storage and Usage

Citations

Target(s)

HDAC3

Formula

C₂₁H₁₉FN₄O

362.4 Da

Solubility

Soluble in DMSO

CAS Registry #

1357389-11-7

Background

RGFP966 is a slow-on/slow-off, competitive tight-binding HDAC inhibitor. RGFP966 treatment on two CTCL cell lines for 24 hours prior to Western blot analysis resulted in increased acetylation at H3K9/K14, H3K27, and H4K5, but not H3K56ac. RGFP966 decreases cell growth in CTCL (cutaneous T cell lymphoma) cell lines due to increased apoptosis that is associated with DNA damage and impaired S phase progression.

References

1. Wells CE, et al. PLoS One. 2013 Jul 22;8(7):e68915.
2. Malvaez M, et al. Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2647-52.

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RGFP966

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