Search results for: 'ipsc'

iPSC-Derived Cells Induced pluripotent stem cells (iPSC), pioneered by Nobel Prize winner Shinya Yamanaka, are generated by converting mature human somatic cells via expression of four critical transcription factors known as Yamanaka factors: Myc, Sox2, Klf4, and Oct3/4. iPSCs are an important tool for research because they are capable of differentiating into various cell types, including those of different tissues and organs. They can be used to study disease mechanisms, drug developm...

Gene & Cell Therapy Gene and cell therapies are paving the way for innovative treatments that can offer new hope for patients with previously untreatable diseases. Gene therapy and cell therapy are cutting-edge medical approaches aimed at revolutionizing healthcare. Gene therapy involves the manipulation and introduction of genetic material into a patient's cells to correct genetic disorders or enhance therapeutic effects. This can be achieved by ...

Research Applications for Engineered iPS Cells Introduction New avenues of research were dramatically opened by the discovery of Takahashi and Yamanaka in 2006 that the ectopic expression of Oct4 (octamer-binding transcription factor 4), Sox2 (SRY-box2), Kfl4 (Kruppel-like factor 4) and c-Myc was sufficient to reprogram terminally differentiated cells into induced pluripotent stem (iPS) cells. These have infinite expansion potential and similar genetic markers, epigenetics and multilineag...

Cell Cytotoxicity Screening & Profiling Services Small Molecule Cell Cytotoxicity Assays Understanding cell cytotoxicity, either as a result of targeted therapy or as a side effect, is important in drug development. Our expert scientists can help determine effective dose curves for your molecules of interest in whole cell assays, whether they are small molecules or biologics, including antibody drug conjugates. Over 30 different tumor cell lines are availabl...

Cell Lines Subscriptions BPS Bioscience cell lines are critical tools for research, providing many novel and versatile solutions across a wide range of drug discovery research areas. To enhance the cell line purchasing experience and satisfy research needs, we are pleased to offer cell line subscriptions. The subscription allows for the purchase of a cell line product with additional vials at low cost, plus the additional optional benefit of cell banking and shipment upon ...

In Vitro Toxicity Research Solutions In vitro toxicity testing plays a critical role in drug development by enabling early and efficient identification of potential safety concerns, reducing reliance on animal testing, and supporting regulatory requirements for drug approval. In vitro toxicity testing plays a critical role in drug development by enabling early and efficient identification of potential safety concern...

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Cell Lines and Primary Cells Cell lines are extremely useful tools for the study of protein interactions, gene activation, cell signaling, viral infection, cell-to-cell communication, and other biological processes in the context of an intact cell system rather than cell-free biochemical assays. BPS Bioscience has developed over 250 stable cell lines applicable across a wide range of research areas including immunotherapy, CAR-T cell therapy, cell signaling, metabolism, neuroscience, and mu...

Cell-Based Assays and Expression Kits Cells can be engineered to serve as readouts for cell-based assays as a complement or alternative to biochemical assays. A variety of cell-based assay types can be used for research and development applications, including signaling pathway analysis, inhibitor/activator studies, CAR-T cell functional screening, ADCC assays, high-throughput screening systems and much more. We provide a variety of cell-based assay express...

Kill Curve Protocol A kill curve allows for determination of the optimal concentration of selection antibiotic to use for selection of an engineered cell line having integrated a construct of interest. Background A kill-curve is a dose-response experiment in which cells are cultivated in the presence of increasing concentrations of a specific antibiotic for a period of one week to ten days. Slow-growing cells may need...

BPS Bioscience License Disclosures iPS Cells License Disclosure The iPSC technology is protected by several patents, including US patent Nos. 8048999, 8058065, 8129187, 8278104, 8530238, 8900871, 9404124, 9499797, 10519425, and patent pending, for which iPS Academia Japan, Inc. has been granted license rights with a sub-licensable right. The purchase of this cell line grants you a 10-year license to use this cell line in your immediate laboratory...

Diabetes & Obesity Breakthrough treatments for diabetes and obesity aim to stem the rising epidemic of complications and deaths directly attributed to these conditions. Diabetes and obesity are two interconnected health conditions that pose significant global challenges. Diabetes is a chronic metabolic disorder characterized by elevated blood sugar levels, resulting from either insufficient insulin production (Type 1 diabetes) or ineffective utili...

Trypan Blue Staining Protocol Trypan blue dye selectively stains dead or damaged cells with compromised cell membranes, allowing them to be distinguished from viable cells. Trypan blue dye selectively stains dead or damaged cells with compromised cell membranes, allowing them to be distinguished from viable cells. Background Trypan blue staining is a widely used technique in cell biology and ...

New Customer Discount Program Make the most out of your first order with us. Place your first order with us as a new customer and get up to a 50% discount . Some restrictions apply. Terms For new US customers only. 10% discount  on Assay Kits , Lentiviruses , and Cell Lines . 30% discount  on ONE-Step™ Luciferase Assay System ( #60690 ), TWO-Step Luciferase (Firefly & Renilla) Assay System ( #60683 ), Western EC...

Cell Lysis Buffers Selecting the right cell lysis buffer is a critical step in many research applications across various scientific disciplines, ranging from molecular biology to cell biology and biochemistry. The choice of cell lysis buffer can significantly impact the quality and reliability of experimental results, making it a fundamental consideration for researchers. This importance stems from several key factors. &n...

Adoptive Cell Therapy Using Antigen-Specific TCRs Engineered T cell receptors provide a promising therapeutic approach to fight cancer by focusing immune cells to target specific antigens. Antigen-specific T-cell receptors (TCRs) play a crucial role in the adaptive immune response by recognizing specific antigen peptides presented by MHC molecules on the surface of infected or abnormal cells. These TCRs are typically found on the surface ...

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The Promise of NK Cell Therapeutics Introduction NK cells are the first line of defense against cancer and have been in the spotlight as a cancer therapy in the last decade. Their advantages versus T cells, such as their safety profile and not requiring MHC (Major Histocompatibility Complex)-antigen stimulation to become cytotoxic, have made NK cells attractive. However, as with T cells, the TME (tumor microenvironment) can suppress their activity, and infiltration into solid tumors is s...