SARS-CoV-2 Coronavirus & COVID-19
There are seven known human coronaviruses , including the novel SARS-CoV-2. Four of these strains cause only mild respiratory symptoms; however, coronaviruses became notorious after outbreaks of Severe Acute Respiratory Syndrome (SARS) in 2002 and Middle East Respiratory Syndrome (MERS) in 2012. The SARS-CoV-2 (2019-nCoV) coronavirus, first identified in late 2019, causes severe pneumonia and respiratory infection (COVID-19).
The S...
Cell Signaling Pathway Screening & Profiling
In order to determine effectors of cell signaling pathways in the context of intact functioning cells, cell-based reporter assays are an ideal option. Using luciferase reporters downstream of a pathway-specific promoter response element, signaling activity can be conveniently measured by the output of luciferase activity. The system can be applied across a wide variety of cell types and signaling pathways and allows for ...
The Promise of NK Cell Therapeutics
Introduction
NK cells are the first line of defense against cancer and have been in the spotlight as a cancer therapy in the last decade. Their advantages versus T cells, such as their safety profile and not requiring MHC (Major Histocompatibility Complex)-antigen stimulation to become cytotoxic, have made NK cells attractive. However, as with T cells, the TME (tumor microenvironment) can suppress their activity, and infiltration into solid tumors is s...
Citations
This page contains a list of scientific journal articles that have cited BPS products and services since 2013. We would like to congratulate all our loyal customers on their contributions to the scientific community. Our customers are truly amazing and dedicated scientists and this is evidenced by the outstanding research they are doing.
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10X HAT Assay Buffer (50095...
Immunotherapy Biochemical Screening Services
Immunotherapy is a type of medical treatment that engages the body's immune system to fight diseases, such as cancer, infections, and autoimmune disorders. It works by either stimulating the immune system to attack cancer cells or other disease-causing agents, or by using synthetic proteins or antibodies to target specific molecules on the surface of cancer cells or other pathogens. Immunotherapy has shown prom...
A2aR & Immunotherapy
The great need for treatments and the promise of cures are driving the search for second-generation immunotherapies beyond therapeutic antibodies targeting PD-1 and CTLA4 pathways. Immunotherapies are not limited to just therapeutic antibodies . Small-molecule inhibitors are showing great promise in clinical trials. For example, inhibitors targeting the enzymatic pathways, such as tryptophan catabolism are in late-phase clinical develop...
OX40 Signaling and Its Implications for Immunotherapy
Introduction
Immune checkpoint OX40, also known as CD134 or TNFRSF4, is a co-stimulatory molecule belonging to the tumor necrosis factor receptor (TNFR) superfamily. Its significance in regulating immune responses has garnered substantial attention in the field of immunotherapy. OX40 signaling plays a crucial role in modulating T cell activation, differentiation, and survival, thereby influencing the outcome of immune responses agains...
Emerging Therapeutic Approaches Against RAS Cancer Mutations
Introduction
RAS (rat sarcoma virus) proteins are small GTPases involved in signal transduction as part of the RAS/MAPK (mitogen-activated protein kinase) pathway and are involved in cell proliferation and differentiation. There are three human RAS genes: KRAS (Kristen rat sarcoma virus), HRAS (Harvey rat sarcoma virus) and NRAS (neuroblastoma rat sarcoma virus). The KRAS gene encodes two isoforms, KRAS-4B and KRAS-4A, but due t...
Claudin-18: A Therapeutic Target in Oncology
Claudins, a family of small tetraspan proteins expressed in a tissue or cell-specific manner, are major components of the multimeric protein architecture of tight junctions, which prevent ions or small molecules from passing freely between epithelial or endothelial cells. These proteins contain four transmembrane domains mainly responsible for interacting side-to-side with neighboring proteins. Two extracellular loops regulate p...
The Power of Lentiviruses in Cell Engineering
Introduction
The ability to manipulate nucleic acids has been a key discovery that has driven research, and ultimately clinical applications, forward. It opened the door to study the impact of mutations in cellular models, dissect pathways, generate recombinant proteins and monoclonal antibodies, and is the basis of gene and cell therapy, continuing to lead to new discoveries and cure patients every day. The methods used to ...
