Search results for: 'bispecific'

Bispecific Antibodies & BiTE® (Bispecific T-Cell Engager) Services   CD3/CD19 BiTE® - Mechanism of Action The CD3/CD19 BiTE® is a biopharmaceutical drug known as a Bi-specific T-cell engager for a second-line treatment for Philadelphia chromosome-negative relapsed or refractory acute lymphoblastic leukemia. It binds to CD19 on cancer cells (e.g. Raji cells) and CD3 on T cells simultaneously, thus bringing T lymphocytes closer to cancer cells expressing specific cancer ...

Bispecific Antibodies & BiTE® (Bispecific T-Cell Engager) Clinical & Therapeutic Research An antibody (Ab) containing two different antigen-binding sites within one molecule is known as a bispecific antibody (BsAb).  BsAb research has expanded greatly within the past ten years. To date, two BsAbs,  Blinatumomab   and Emicizumab, have been approved in the US and the EU, while a third BsAb, Catumaxomab, is already commercially available in the EU. Additionally, th...

ADC and Antibody-Based Cancer Therapies Antibody-based therapies, such as antibody-drug conjugates (ADCs) and multi-specific T cell engager molecules, provide a targeted approach to treating cancers. Antibody-based therapies, such as antibody-drug conjugates (ADCs) and multi-specific T cell engager molecules, provide a targeted approach to treating cancers. Monoclonal antibodies, which are laboratory-produced molecules that bind to a specif...

Conferences & Events Immuno-Oncology Summit, Booth #2 August 7-9, 2024 (Philadelphia, PA) Immuno-Oncology Summit explores bi- and multispecific biotherapeutics; highlighting the latest developments in CAR T therapies, emerging targeting technologies, personalized immunotherapy, and cell-based immunotherapies; and addressing the challenges of overcoming tumor resistance. Attendees delve into predictive models, tumor microenvironment modulation, and the increasing role o...

BCMA Research Products B cell maturation antigen (BCMA), a cell surface protein primarily expressed by mature B cells and antibody-producing plasma cells, is an effective immunotherapy target for treating multiple myeloma and other B cell disorders. BCMA, also known as TNFRSF17 belonging to the TNF receptor superfamily, binds to APRIL/TNFSF13 and BAFF/TNFSF13B/CD257 and regulates B cell development and survival, as wel...

CD19 Research Products CD19, a cell surface protein specific to B cells, has emerged as an effective immunotherapy target to treat B cell malignancies and autoimmune diseases. By leveraging monoclonal antibodies, chimeric antigen receptor (CAR) T cells and NK cells, or bispecific T cell/NK cell engagers (BiTEs/BiKEs), CD19-directed immunotherapies aim to selectively eliminate CD19-expressing cells. In cancer, these ther...

Bioluminescent Cells for Cell Line-Derived Xenograft (CDX) Models Cell line-derived xenograft (CDX) models are important in vivo models that serve to determine anti-tumor efficacy, pharmacokinetics/pharmacodynamics, toxicity, and other characteristics of drug candidates. They can be used effectively across a range of therapeutic modalities, including small molecules, antibodies, and CAR-T, among others. BPS Bioscience has specifically engineered human-derived cell lines constitutively expr...

Technical Notes and Application Notes Immunotherapy | Cancer Targets | CAR-T/NK Cell Therapy | Gene & Cell Therapy | Cell Culture | RNA Editing | Cancer Pathways | CRISPR/Cas9 | Cell Receptor Targets | Ubiquitination | Protein Conjugation | Technology | Cholesterol Pathways | SARS-CoV-2/COVID-19 Immunotherapy OX40 Signaling and Its Implications for Immunotherapy TL1A:DR3 - A Pathway for Immunomodulation Therape...

Siglecs & Immunotherapy BPS has released a number of Siglec proteins and stable cell lines for studying immune-oncology and immune regulation . Cells of the immune system express a multitude of complex glycans on their surfaces, making them highly recognizable by diverse glycan-binding proteins. Siglecs (Sialic-acid-binding immunoglobulin-like lectins) are type I transmembrane proteins that bind to glycans containing sialic acid. These highly polymorphic proteins have very dist...

Targeted Protein Degradation Approaches and Applications Introduction Traditional approaches to regulate protein activity have relied on direct protein interactions by using inhibitors or ligands. However, these target only about 10% of the known 4000 disease-linked proteins, with many being considered “undruggable” due to their quaternary structure. In recent years new strategies to target “undruggable” proteins have been developed, harnessing the power of the cells’ own protei...

Natural Killer Cells Natural Killer (NK) cells are lymphocytes involved in the innate immune system that respond to infected cells and tumor cells, limiting these pathologies. They are now considered potential tools for adoptive cell therapies. Natural Killer (NK) cells are lymphocytes involved in the innate immune system that respond to infected cells and tumor cells, limiting these pathologies. They are now considered potential tools for adoptive cel...

Cell Cytotoxicity Screening & Profiling Services Small Molecule Cell Cytotoxicity Assays Understanding cell cytotoxicity, either as a result of targeted therapy or as a side effect, is important in drug development. Our expert scientists can help determine effective dose curves for your molecules of interest in whole cell assays, whether they are small molecules or biologics, including antibody drug conjugates. Over 30 different tumor cell lines are availabl...

Claudin-18: A Therapeutic Target in Oncology Claudins, a family of small tetraspan proteins expressed in a tissue or cell-specific manner, are major components of the multimeric protein architecture of tight junctions, which prevent ions or small molecules from passing freely between epithelial or endothelial cells. These proteins contain four transmembrane domains mainly responsible for interacting side-to-side with neighboring proteins. Two extracellular loops regulate p...

Cancer & Immunotherapy Immunotherapy is revolutionizing cancer treatment by unleashing the power of the body’s immune system against tumors. Immunotherapy is revolutionizing cancer treatment by unleashing the power of the body’s immune system against tumors. Cancer is a complex group of diseases characterized by the uncontrolled growth and spread of abnormal cells. It can affect virtually any tissue or organ in the body and may manifest as...

Targeting BCMA in Mutliple Myeloma Multiple Myeloma Multiple myeloma is the second most commonly diagnosed blood cancer, after non-Hodgkin lymphoma. Multiple myeloma is a cancer in which immortalized plasma cells accumulate in the bone marrow, causing severe pain, anemia, and kidney failure. Multiple myeloma was once considered universally fatal. Improved diagnostic methods and innovative treatments are improving patient outcomes. Still, nearly all patients eventually relapse a...

Mechanism of JAK-STAT Signaling in Cancer Cell Signaling Pathways Understanding cell to cell communication through cytokines and other secreted factors is at the center of daily life for countless pharmaceutical researchers.  This is because cytokine-based communication is central to normal development and is often a dysfunctional step in cancer and autoimmune diseases ( 1, 2 ).  It is also of increasing importance because cytokine release syndrome is a leading caus...

Structure and Function of the Claudin Family Introduction Claudins (encoded by the multi-gene family CLDN) are tetraspan membrane proteins found in all epithelial and endothelial cells. They serve as crucial structural components of tight junction strands, where the membranes of two adjacent cells connect to form a barrier by self-polymerization and transcellular interactions at the apical-lateral membrane of epithelia. The tight junctions prevent molecules from passing bet...

Citations   This page contains a list of scientific journal articles that have cited BPS products and services since 2013. We would like to congratulate all our loyal customers on their contributions to the scientific community. Our customers are truly amazing and dedicated scientists and this is evidenced by the outstanding research they are doing.  Search By Product Name or Catalog Number Name Title 10X HAT Assay Buffer (50095...