Combining Therapies for Targeting Immune Checkpoints
| IMMUNE CHECKPOINTS | | KINASES | | PARPS | | HDACS | | CAR T-CELL THERAPY |
Cancer is a balance between the defens...
CD39 & CD73: Adenosine Signaling
Therapeutic antibodies targeting checkpoint receptors such as PD-1 and CTLA4 are giving new hope to cancer patients. However, not all patients respond to treatment and the search for effective co-therapies is driving substantial research. Two critical enzymes of this pathway, CD39 and CD73 , are promising targets for increasing the effectiveness of checkpoint-based immunotherapies. 1
The hydrolysis of extracellular ATP to AMP is...
LAG3 as a Cotherapy for Immune Checkpoints
Cotherapy with PD-1
Therapeutic antibodies targeting the immune checkpoint receptors PD-1 and CTLA4 substantially changed the prognosis for many cancer patients. When successful, these treatments extend lives. Still, cancer is relentless. Only a relatively small number of patients respond or have substantial remission when these treatments are used as monotherapies.
Much of the current research on immunomodulating r...
A2aR & Immunotherapy
The great need for treatments and the promise of cures are driving the search for second-generation immunotherapies beyond therapeutic antibodies targeting PD-1 and CTLA4 pathways. Immunotherapies are not limited to just therapeutic antibodies . Small-molecule inhibitors are showing great promise in clinical trials. For example, inhibitors targeting the enzymatic pathways, such as tryptophan catabolism are in late-phase clinical develop...
HVEM, LIGHT & BTLA: New Immunotherapy Target
The checkpoint receptors HVEM , LIGHT , CD160 , and BTLA are part of a complex network of overlapping receptor interactions that function in both immune stimulation and suppression 1 , 2 . This regulatory function has made them therapeutic targets for treatment of cancer, autoimmune diseases and allergies, and for improved methods of organ transplants. While presenting opportunities for...
Immunotherapy Biochemical Screening Services
Immunotherapy is a type of medical treatment that engages the body's immune system to fight diseases, such as cancer, infections, and autoimmune disorders. It works by either stimulating the immune system to attack cancer cells or other disease-causing agents, or by using synthetic proteins or antibodies to target specific molecules on the surface of cancer cells or other pathogens. Immunotherapy has shown prom...
Immune Checkpoint Molecules
Immune checkpoint molecules are crucial components of the immune system that regulate the intensity and duration of immune responses but have been usurped by cancer cells and pathogens to evade the immune system.
Immune checkpoint molecules are crucial components of the immune system that regulate the intensity and duration of immune responses but have been usurped by cancer cells and pathogens...
TIGIT, CD155, & CD226
Promising Targets for Cancer Immunotherapies
It’s possible someone you know has benefited from cancer treatments based on checkpoint receptors. Therapeutic antibodies targeting PD-1 and CTLA-4 pathways have already added years to the lives of lucky patients. Unfortunately, not everyone responds to these treatments. This resistance drives the search for new therapies to extend the successes of existing PD-1 and CTLA-4-based treatme...
Citations
This page contains a list of scientific journal articles that have cited BPS products and services since 2013. We would like to congratulate all our loyal customers on their contributions to the scientific community. Our customers are truly amazing and dedicated scientists and this is evidenced by the outstanding research they are doing.
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10X HAT Assay Buffer (50095...
