UNC0224

Catalog #
27303
$270 *
Size: 5 mg
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Description

UNC0224 is a potent and selective inhibitor of G9a, a histone methyltransferase (HMT). It also inhibits GLP, a closely-related H3K9 HMT, but is more than 1,000-fold selective against SET7/9 and SET8.

Product Info
Storage and Usage
Citations
Purity

≥98% by HPLC

Format
A crystalline solid.
Formula
C26H43N7O2
MW
485.7 kDa
Solubility
Soluble in DMSO, DMF and ethanol, purged with an inert gas. Solubility in DMSO and DMF is approximately 2 mg/ml, and solubility in ethanol is ~15 mg/ml.
Biological Activity
UNC0224 inhibits G9a with an IC50 value of 15 nM. It has been shown to inhibit GLP with assay-dependent IC50 values of 20-58 nM.
CAS Registry #
1197196-48-7
References
1. Tachibana, M., et al., Genes Dev. 2002; 16:1779-1791.
2. Wagschal, A., et al., Mol. Cell. Biol. 2008; 28(3):1104-1113.
3. Thomas, L.R., et al., J. Immunol. 2008; 181:485-493.