Chaetocin
Catalog #
27221
$235
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Description
Chaetocin is an inhibitor of histone methyltransferases (HMTs) including SUV39H1 and Lys9-specific HMTs such as G9a. It also has some inhibitory effects on SET7, EZH2, and SET7/9. Chaetocin can also induce cellular oxidative stress, selectively killing cancer cells and rapidly-proliferating primary cells. It is a fungal myotoxin. The inhibitor is useful in epigenetics and cancer research.
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Product Info
Storage and Usage
Citations
Purity
≥95% by HPLC
Format
A crystalline solid.
Formula
C30H28N6O6S4
MW
696.8 Da
Solubility
Soluble in organic solvents purged with an inert gas and solubility is 25 mg/ml.
Biological Activity
Chaetocin inhibits SUV39H1 with an IC50 = 0.8 µM, G9a with an IC50 = 2.5
µM , and DIM5 with an IC50 = 3 µM .
CAS Registry #
28097-03-2
References
1. Greiner, D., et al., Nat. Chem. Biol. 2005;1(3):143-145.
2. Isham, C.R., et al., Blood 2007;109(6):2579-2588.
3. Tibodeau, J.D., et al., Antioxid. Redox Signal. 2009;11(5):1097-1106.
2. Isham, C.R., et al., Blood 2007;109(6):2579-2588.
3. Tibodeau, J.D., et al., Antioxid. Redox Signal. 2009;11(5):1097-1106.