BIX01294 (hydrochloride hydrate)
Catalog #
27220
$225
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Description
BIX01294 (hydrochloride hydrate) is a selective inhibitor of G9a, a histone methyltransferase (HMT). It can also inhibit G9a-like protein (GLP), but is less effective. There are no known inhibitory effects on other HMTs. Also, BIX01294 has been used in combination with Bay-K8644 to facilitate generation of induced pluripotent stem cells from somatic cells in vitro.
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Product Info
Storage and Usage
Citations
Purity
≥98% by HPLC
Format
A crystalline solid.
Formula
C28H38N6O2 • 3HCl [XH2O]
MW
600 Da
Solubility
Dissolve in water or other aqueous buffers. Solubility in water is ~20 mg/ml.
Biological Activity
BIX01294 inhibits G9a with an IC50 = 1.7 µM, and GLP with an IC50 = 38 µM.
CAS Registry #
935693-62-2
References
1. Tachibana, M., et al., Genes Dev. 2002; 16:1779-1791.
2. Wagschal, A., et al., Mol. Cell. Biol. 2008; 28(3):1104-1113.
3. Thomas, L.R., et al., J. Immunol. 2008; 181:485-493.
2. Wagschal, A., et al., Mol. Cell. Biol. 2008; 28(3):1104-1113.
3. Thomas, L.R., et al., J. Immunol. 2008; 181:485-493.
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