PTP1B(1-321)/PTPN1, GST-tag Recombinant
Catalog #
30010
$325
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Description
Human PTP1B protein tyrosine phosphatase, also known as PTPN1 (GenBank accession no. M31724), a.a. 1-321 (catalytic domain), with N-terminal GST-tag, MW=63.3 kDa, expressed in E. coli.
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Synonyms
PTP1B, PTPN1, Protein tyrosine phosphatase 1B, ptp
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Product Data Gallery
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
E. coli
Purity
≥90%
Format
Aqueous buffer solution
Formulation
25 mM Tris-HCl, 75 mM NaCl, pH 8.0, 0.05% Tween-20, 10 mM glutathione, 1 mM DTT and 50% glycerol
MW
63.3 kDa
Amino Acids
1–321
Specific Activity
780 pmole/min/µg
Genbank #
M31724
UniProt #
P18031
Background
Protein tyrosine phosphatase nonreceptor, type 1 (PTPN1) is the founding member of the protein tyrosine phosphatase (PTP) family. PTPN1 catalyze the hydrolysis of the phosphate monoesters specifically from tyrosine residues. PTPN1 is known to be involved in signaling pathways that regulate a variety of cellular processes including cell growth and oncogenic transformation. PTPN1 also has been shown to act as a negative regulator of insulin signaling. PTPN1 has also been reported to dephosphorylate epidermal growth factor receptor kinase, which implicated the role of this phosphatase in cell growth control and cell response to interferon stimulation.
References
1. Frangioni et al., Cell, 1992, 68: 545.
2. M. Elchebly et al., Science 1999, 283: 1544.
2. M. Elchebly et al., Science 1999, 283: 1544.