MNK2, GST-tag Recombinant
Catalog #
40128
$410
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Description
Recombinant human MNK2 (MAP kinase interacting serine/threonine kinase 2), also known as GPRK7 (G protein-coupled receptor kinase 7), GenBank Accession No. NM_017572, full length, with N-terminal GST tag, MW ~74 kDa, expressed in Sf9 insect cells via a baculovirus expression system.
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Synonyms
MKNK2; GPRK7
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Product Data Gallery
10% SDS-PAGE Coomassie Staining
Specific Activity
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
Sf9 insect cells
Purity
≥70%
Format
Aqueous buffer solution
Formulation
50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.
MW
74 kDa
Amino Acids
full length
Specific Activity
84 pmol/min/µg
Genbank #
NM_017572
UniProt #
Q9HBH9
Background
MNK2 (MAP kinase-interacting kinase 2) contains a conserved C-terminal ERK-interacting domain, a catalytic domain with homology to the calcium/calmodulin-dependent family of kinases, and putative MAP kinase phosphorylation sites located within the T loop of the kinase domain. MNK2 binds tightly to the growth factor-regulated MAP kinases, ERK1 and ERK2. ERK and p38 phosphorylate MNK2, which stimulates its in vitro kinase activity toward a substrate, eukaryotic initiation factor-4E (eIF-4E) (1). A yeast two-hybrid screen showed the Mnk2 protein interacted with the ligand-binding domain of estrogen receptor beta (ERbeta) (2).
References
1. Waskiewicz, A J. et al: Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. EMBO J. 1997 Apr 15;16(8):1909-20.
2. Slentz-Kesler, K. et al: Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta. Genomics. 2000 Oct 1;69(1):63-71.
2. Slentz-Kesler, K. et al: Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta. Genomics. 2000 Oct 1;69(1):63-71.
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