KRAS (G12V), Isoform B, His-Tag, GppNHp-Loaded Recombinant
Recombinant human KRAS (GTPase), isoform b, encompassing amino acids 2-185. This construct contains an N-terminal His-tag (6xHis). The protein also contains the mutation of interest G12V. The protein (BPS Bioscience #100480) was affinity purified and loaded with GppNHp, a non-hydrolyzable GTP analog. Unbound GppNHp was removed by spin column.
≥90%
Aqueous buffer solution
20 mM HEPES, pH 7.4, 150 mM NaCl, and 1 mM DTT
KRAS (Kirsten rat sarcoma virus) is a GTPase part of the RAS/MAPK pathway, being involved in signal transduction for cell proliferation and differentiation. KRAs is a proto-oncogene and mutations in it are responsible for more than 30% of human cancers, such as leukemia, lung adenocarcinoma, pancreatic and colorectal cancer. Although new treatments have been recently developed to mitigate the tumor-promoting effects of RAS mutations, one mutant, KRAS (G12V), has been resistant to most known inhibitors. New compounds that affect the nucleotide exchange (GDP to GTP) reaction in KRAS mutant G12V are expected to inhibit tumor cell growth in KRAS (G12V)-driven tumors.
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