Human Interleukin-2 Recombinant

Catalog #

90184-A

$130 *

Size: 10 µg

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Description

Recombinant Interleukin-2 is a disulfide-linked monomer protein consisting of 133 amino acid residues, migrates as an approximately 15 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding human Interleukin-2 mature chain was expressed in E. coli.

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Synonyms

IL-2, Lymphokine, TCGF, T Cell Growth Factor, Aldesleukin, Interleukin-2, IL2

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

E. coli

Purity

≥97% by SDS-PAGE and HPLC

Format

lyophilized protein

Formulation

Lyophilized from 0.2 µm filtered concentrated (1 mg/ml) solution in PBS, pH 7.2.

15 kDa

Endotoxin Level

<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.

Amino Acids

21–153

Biological Activity

The ED₅₀ was determined by the dose dependent proliferation of murine CTLL-2 cells and was found to be less than 0.1 ng/ml , corresponding to a specific activity of >2.0x 10⁷units/mg.

Genbank #

P60568

UniProt #

P60568

Background

IL-2 is produced mainly by T- cells expressing the surface antigen CD4 following cell activation by mitogens or allogen. Interleukin-2 (IL-2) has multiple, sometimes opposing, functions during an inflammatory response. It is a potent inducer of T-cell proliferation and T- helper 1 (Th1) and Th2 effector T-cell differentiation and provides T cells with a long-lasting competitive advantage resulting in the optimal survival and function of memory cells. In a regulatory role, IL-2 is important for the development, survival, and function of regulatory T cells, it enhances Fas-mediated activation-induced cell death, and it inhibits the development of inflammatory Th17 cells. Thus, in its dual and contrasting functions, IL-2 contributes to both the induction and the termination of inflammatory immune responses.

References

1. Shevach EM. Trends Immunol. 2012 Dec,33(12):626-32.
2. Dooms H, Abbas AK. Eur J Immunol. 2010 Jun,40(6):1538-40.

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Human Interleukin-2 Recombinant

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