CD123, Avi-Tag, His-Tag, Biotin-Labeled Recombinant
Recombinant human CD123 (also known as IL3Ra , interleukin 3 receptor alpha) encompassing amino acids 20-305 (end). This construct contains a C-terminal Avi-Tag™ followed by a C-terminal His-tag (6xHis). The recombinant protein was affinity purified.
≥90%
Aqueous buffer solution.
8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
This protein is enzymatically biotinylated using Avi-Tag™ technology. Biotinylation is confirmed to be ≥90%.
For more information on enzymatic biotinylation, please see our Tech Note.
CD123, also known as interleukin 3 receptor alpha (IL3Ra), is a cell surface receptor found in pluripotent progenitor cells and involved in hematopoietic lineage differentiation. It can also be found in basophils, plasmacytoid dendritic cells and dendritic cells. CD123 is overexpressed on leukemic hematopoietic stem cells (HSCs), but not normal HSCs. It has been found in acute myeloid and B-lymphoid leukemias, blastic plasmacytoid dendritic neoplasms (BPDCN), and hairy cell leukemia. This expression profile makes CD123 an attractive target in cancer therapy. CAR-Ts and other therapies targeting CD123 are being evaluated in clinical trials.
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