Search results for: 'spike'

SARS-CoV-2 Coronavirus Variants The COVID-19 pandemic, caused by the novel  SARS-CoV-2 coronavirus , has ravaged the globe, infecting over 450 million people and causing over 6 million deaths as of early 2022. The recent emergence of new SARS-CoV-2 variants is a severe concern, especially omicron and delta variants, as many of these mutations occur within the Spike protein and appear to increase transmissibility and infectivity. The graphics belo...

Lentiviruses for SARS-CoV-2 Research To understand the mechanism of SARS-CoV-2 cell entry, it is essential to study how Spike proteins interact with the ACE2 receptor. However, such studies are hampered by the danger of producing and manipulating live coronavirus. A safer alternative to using live coronavirus is to use recombinant lentivirus pseudotyped with the coronavirus S protein. The Spike pseudotyped lentivirus includes a luciferase reporter, allowing the monitoring of viral entry into...

Coronavirus Services Biochemical Screening Cell-Based Services Cell Lines /CRISPR Protein Binding Studies/BLI BPS Bioscience has developed innovative proteins , cell lines , lentiviruses , and assay kits , to enable a wide range of preclinical activities for investigating potential COVID-19 antiviral drugs. These kits and services aim to rapidly advance drugs into the clinic by screening for compounds that prevent the ...

SARS-CoV-2 Variants: Evading the Immune System The COVID-19 pandemic, caused by the novel SARS-CoV-2 coronavirus , has ravaged the globe, infecting over 145 million people and causing over 3 million deaths as of the time of this article. Ending the pandemic will require a combination of effective interventions, including therapeutics, diagnostics, and vaccines.  Several monoclonal antibody therapeutics have received emergency use authorization, and a number of vaccines have been devel...

SARS-CoV-2 Coronavirus & COVID-19 There are seven known human coronaviruses , including the novel SARS-CoV-2. Four of these strains cause only mild respiratory symptoms; however, coronaviruses became notorious after outbreaks of Severe Acute Respiratory Syndrome (SARS) in 2002 and Middle East Respiratory Syndrome (MERS) in 2012. The SARS-CoV-2 (2019-nCoV) coronavirus, first identified in late 2019, causes severe pneumonia and respiratory infection (COVID-19).  The S...

Lentiviruses Lentiviral transduction is a powerful tool for introducing genes into cells and is used extensively for cellular engineering. It has recently made its way to the clinic with ex-vivo cell therapy applications. Lentiviruses (LV) have also been used extensively for the modeling of SARS-CoV-2 viral infection of human cells. Lentiviral transduction is a powerful tool for introducing genes into cells and is used extensively for cellular engineering...

SARS-CoV-2 Antibody Detection SARS-CoV-2 has spread across the globe effectively at a rapid pace causing a worldwide pandemic. Infection with this highly contagious respiratory virus can be asymptomatic or present as COVID-19, a disease with varying degrees of severity. Clinical symptoms may include fever, dry cough, anosmia, gastrointestinal symptoms, hypercoagulability, hyperimmune response (cytokine storm), and acute respiratory distress syndrome (ARDS) with disease progression (1). Patie...

VSV Tools VSV (Vesicular stomatitis virus) is an enveloped, negative-stranded RNA virus with a simple structure. Its ability to infect a wide range of mammalian cell types has made VSV a valuable tool to study virus entry, replication, and assembly. The glycoprotein of VSV (termed VSV-G), which binds to the LDL-receptor (low-density lipoprotein receptor), is responsible for the attachment and entry of VSV into a susceptible host cell. The VSV-G glycoprotein can be deleted from the VSV (V...

Virus-Based Tools Virus-based tools such as Lentivirus, Adeno-Associated Virus (AAV), and Vesicular Stomatitis Virus (VSV) are critical for cell engineering and the study of viral infection.  We have designed a suite of ready-to-use viral reagents to address a wide span of research areas including virology (particularly Coronaviruses), immunotherapy, CAR-T therapy, CRISPR, cell signaling, and more.        Lentiviruses Ideal for pseudotyp...

Viral Tools Frequently Asked Questions FAQ Topic: -Any- General Lentiviruses AAVs FAQ Search: How should I store the viral particles (lentivirus, AAV or VSV) that I just rec...

Proteases as Targets for SARS-CoV-2 Treatment Researchers have shown that proteases are actively used by SARS-CoV-2 for it’s entry and replication into human cells. To support research on this topic, BPS Bioscience provides a range of screening kits to identify inhibitory compounds directed against these human and viral proteases. SARS-CoV-2’s mechanism of entry and replication into human cells is now well known and described by the scientific community. The penetration steps can be d...

Technical Notes and Application Notes Immunotherapy | Cancer Targets | CAR-T/NK Cell Therapy | Gene & Cell Therapy | Cell Culture | Cancer Pathways | CRISPR/Cas9 | Cell Receptor Targets | Ubiquitination | Protein Conjugation | Technology | Cholesterol Pathways | SARS-CoV-2/COVID-19 Immunotherapy A2aR & Immunotherapy BCMA & Cancer Bispecific Antibodies Combination Therapies for Targetin...

SARS-CoV-2 Accessory Proteins & ORF9b Coronavirus SARS-CoV-2 is an enveloped virus that interacts with host cells via a protruding protein called Spike , and fuses with the cellular membrane to inject its genome into the cell. The SARS family of coronaviruses contain a large single stranded RNA genome of about 30 kb with both unique and conserved features compared to other coronaviruses [1]. The presence of a 5′ methylated cap and a 3′ poly-adenylated tail allows the posit...

Protein Binding Studies / BLI Detection Services Bio-Layer Interferometry (BLI) is a powerful analytical technique for studying biomolecular interactions. BLI measures changes in interference patterns of light reflected from a biosensor tip, which is typically coated with a layer of molecules relevant to the study. As biomolecules bind to or dissociate from the biosensor surface, the interference patterns change, providing real-time data on the kinetics and affinity of these int...

Custom Lentivirus Services BPS Bioscience has developed a diverse portfolio of lentivirus products to study COVID-19 , cell signaling pathways , CAR T-cell therapy , CRISPR , and immunotherapy . In addition to our product portfolio , we also offer custom services to develop a lentivirus suited for your research needs.  Customizable Options Reporters ( GFP , Luciferase , Dual Reporter ) Antibiotic selection markers ( Puromycin , Hygromycin , G4...

Frequently Asked Questions BPS Bioscience is here to answer your questions and provide project guidance. On the following pages, we outline some of the most frequently asked questions separated by product type. If your question is not answered through these resources, please contact us today and we are happy to assist.  Proteins Cell Lines Assay Kits ...

Citations   This page contains a list of scientific journal articles that have cited BPS products and services since 2013. We would like to congratulate all our loyal customers on their contributions to the scientific community. Our customers are truly amazing and dedicated scientists and this is evidenced by the outstanding research they are doing.  Search By Product Name or Catalog Number Name Title 10X HAT Assay Buffer (50095...

Screening and Profiling Services Evaluate lead compounds with our biochemical and cell-based screening services to identify specific inhibitors or activators. Save time by letting us screen your small molecules or biologics of interest against our unique assay panels or determine IC 50 values. With our portfolio of > 600 assays available as a service, we’re here to help advance your drug discovery program. Our biochemical-based inhibitor...