Methods For Drug Discovery
Immunotherapies based on targeting the PD-1:PD-L1 immune checkpoint pathway are having clinical impact and are giving new hope to cancer patients. However, positive response to treatment is not guaranteed and resistance remains a concern. Improving outcomes based on immunotherapy requires multiple approaches for manipulating the complexities of the immune system and tumor microenvironment. To meet these challenges, a series of r...
HVEM, LIGHT & BTLA: New Immunotherapy Target
The checkpoint receptors HVEM , LIGHT , CD160 , and BTLA are part of a complex network of overlapping receptor interactions that function in both immune stimulation and suppression 1 , 2 . This regulatory function has made them therapeutic targets for treatment of cancer, autoimmune diseases and allergies, and for improved methods of organ transplants. While presenting opportunities for...
Virus-Based Tools
Virus-based tools such as Lentivirus, Adeno-Associated Virus (AAV), and Vesicular Stomatitis Virus (VSV) are critical for cell engineering and the study of viral infection. We have designed a suite of ready-to-use viral reagents to address a wide span of research areas including virology (particularly Coronaviruses), immunotherapy, CAR-T therapy, CRISPR, cell signaling, and more.
Lentiviruses Ideal for pseudotyp...
Citations
This page contains a list of scientific journal articles that have cited BPS products and services since 2013. We would like to congratulate all our loyal customers on their contributions to the scientific community. Our customers are truly amazing and dedicated scientists and this is evidenced by the outstanding research they are doing.
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10X HAT Assay Buffer (50095...
CRISPR-Based Synergistic Activation Mediator (SAM)
Introduction
Cas9 ( Streptococcus pyogenes CRISPR-associated protein 9) is a sequence-specific prokaryotic endonuclease that is recruited to the DNA by a single guide RNA (sgRNA) and introduces a double stranded break into the DNA. This double stranded break is usually repaired through Non-Homologous End Joining (NHEJ) in mammalian cells (1) . The target DNA sequence requires only 23 bp (base pairs) in length and sho...
IgG Antibodies and Fcγ Receptors in Immunotherapy
IgG Antibodies and Fcγ Receptors in Immunotherapy
Monoclonal, immunoglobulin G (IgG), antibodies are the basis of powerful therapies for treating cancer, viral infections, and autoimmune disease. The power of therapeutic antibodies comes from their ability to bind antigen targets with high specificity and then harness the functions of the larger the immune system. There are a variety of immune responses. Cytotoxic anti...
