B7-H7 (HHLA2)/TCR Activator CHO Cell Line
Recombinant CHO-K1 cells stably expressing human B7-H7 (also known as HHLA2: HERV-H LTR-associating protein 2, GenBank accession #NM_007072) and an engineered T cell receptor (TCR) activator. B7-H7 mediates an immune-stimulatory signal via TMIGD2 (Transmembrane and immunoglobulin domain containing 2) in naïve T cells while delivering an immune-inhibitory signal through KIR3DL3 in activated T cells and Natural Killer (NK) cells.
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Materials Required for Cell Culture
Name | Ordering Information |
Thaw Medium 3 | BPS Bioscience #60186 |
Growth Medium 3A | BPS Bioscience #60188 |
Materials Required For Cellular Assay
Name | Ordering Information |
Anti-HHLA2(B7-H7) antibody1 | Bahatt RS, 2021 (see references) |
Growth Medium 3A | BPS Bioscience #60188 |
Assay Medium: Thaw Medium 2 | BPS Bioscience #60184 |
KIR3DL3/IL-2 Luciferase Reporter Jurkat Cell Line | BPS Bioscience #78322 |
TMIGD2/NFAT Luciferase Reporter Jurkat Cell Line | BPS Bioscience #78323 |
Anti-CD28 Agonist Antibody | BPS Bioscience #100186 |
96-well tissue culture treated, white clear-bottom assay plate | Corning #3610 |
ONE-Step™ Luciferase Assay System | BPS Bioscience #60690 |
Luminometer |
The cell line has been screened to confirm the absence of Mycoplasma species.
Bahatt RS, et. al., Cancer Immunol Res. 2021 Feb;9(2):156-169.