Azacytidine (Vidaza)

Catalog #

27107

$230 *

Size: 50 mg

Qty

Bulk/Custom

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Description

Azacitidine is also known as Vidaza, 5-azacytidine, Mylosar, and Ladakamycin. Azacitidine and its deoxy derivative, decitabine (5-aza-2'deoxycytidine), are used in the treatment of myelodysplastic syndrome. The azacytidine in the DNA forms a stable complex with DNA methyltransferase enzymes, preventing DNMT activity and resulting in hypomethylation of cellular DNA. Likewise, the incorporation of azacytidine into RNA leads to the dissembly of polyribosomes, defective methylation and inhibition of protein production with subsequent cytotoxicity.

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Synonyms

Vidaza, 5-azacytidine, Mylosar, and Ladakamycin

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Product Data Gallery

Product Info

Storage and Usage

Citations

Purity

≥99% by HPLC

Format

White to off-white solid

Formula

C₈H₁₂N₄O₅

244.2 Da

Solubility

Soluble in DMSO. Insoluble in acetone, ethanol, and methyl ethyl ketone. Slightly soluble in ethanol/water combination of fifty-fifty, and propylene glycol.

Biological Activity

When testing anti-tumor effects in prostate cancer the antiproliferative effect of azacitidine treatment in 22rv1 cells and PC3 cells, the IC50’s were 0.5 µM and 2.5 µM respectively.

CAS Registry #

320-67-2

References

Vigushin DM et al. Clin Cancer Res. 2001 Apr;7(4):971-6.

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Azacytidine (Vidaza)

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