Anti-CD235a IgG1 Antibody, Biotin-Labeled
Anti-CD235a antibody is a purified biotinylated recombinant human antibody which recognizes the human CD235a/GYPA protein. The heavy chain contains a C-terminal Avi-Tag™. This antibody has been tested for specific binding to purified human CD235a protein (BPS Bioscience #101196) in a colorimetric ELISA.
≥90%
Aqueous buffer solution
8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
This protein is enzymatically biotinylated using Avi-Tag™ technology. Biotinylation is confirmed to be ≥90%.
For more information on enzymatic biotinylation, please see our Tech Note.
CD235a, also known as Glycophorin A (GYPA), is a sialoglycoprotein and a major intrinsic membrane protein on the surface of human erythrocytes. CD235a plays an important role in the prevention of red cell aggregation in the circulatory system. The Glycophorin A gene contains some antigenic alleles of the MNS blood grouping system for which 40 known variants exist. Several of these antigenic variants have implications for pathogen interaction. For example, the Wright b antigen in the helical region of Glycophorin A acts as a receptor for the malaria parasite Plasmodium falciparum. Other variations such as the Mur phenotype cause hemolytic transfusion reaction (HTR) and hemolytic disease in the newborn fetus (HDFN). CD235a is one of the most abundant integral proteins of the red cell membrane, and its genetic sequence varies within a population; therefore, it may also support applications in forensic science.
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