Anti-CD16a Antibody, PE-Labeled
This human anti-CD16a antibody is a purified recombinant antibody, which is labeled with R-Phycoerythrin (PE). This antibody has been tested by flow cytometry for binding to human CD16a on the surface of the CD16a CHO Recombinant Cell Line (BPS Bioscience #78332).
≥90%
Aqueous buffer solution.
8 mM Phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, 0.09% Sodium Azide, 0.2% BSA, and up to 20% glycerol. May contain a protein stabilizer.
PE is an oligomeric protein complex (270 kDa) from red algae that exhibits intensely bright red-orange fluorescence with excitation peak at 566 nm and an emission peak at 574 nm. The complex consists of six heterodimers, α subunit (18 kDa) and β-subunit (20 kDa), and an additional γ-subunit (34 kDa).
CD16a, also known as Fc Gamma Receptor 3A (FcGRIIIA; FcγRIIIA), is a low/intermediate affinity receptor for polyvalent immune-complexed IgG. It is involved in phagocytosis, antibody-dependent cytotoxicity, and clearance of immune complexes. The human FcGR3A displays a dimorphism at residue 158. The allele V158 encodes a higher Fc affinity receptor variant while the allele F158 encodes a lower Fc affinity receptor variant. FcGR3A (CD16a) plays a role in the activation of natural killer (NK) cells, and it is extensively used as a cell marker. Its expression has also been observed at the surface of T cells in patients with chronic viral infections (such as COVID-19). Binding to CD16a can potentiate the efficacy of therapeutic antibodies used to treat solid tumors. In addition, CD16a is a biomarker in hematopoietic cancers and an interesting therapeutic target.
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