Anti-CD16a Antibody, FITC-Labeled
This human anti-CD16a antibody is a purified recombinant antibody, which is labeled with fluorescein isothiocyanate (FITC). This antibody has been tested by flow cytometry for binding to human CD16a on the surface of the CD16a CHO Recombinant Cell Line (BPS Bioscience #78332).
≥90%
Aqueous buffer solution.
8 mM Phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, 0.09% Sodium Azide, 0.2% BSA, and up to 20% glycerol. May contain a protein stabilizer.
Fluorescein isothiocyanate (FITC) is a derivative of fluorescein and has excitation and emission spectrum peak wavelengths of approximately 495 nm and 519 nm, causing it to fluoresce green.
CD16a, also known as Fc Gamma Receptor 3A (FcGRIIIA; FcγRIIIA), is a low/intermediate affinity receptor for polyvalent immune-complexed IgG. It is involved in phagocytosis, antibody-dependent cytotoxicity, and clearance of immune complexes. The human FcGR3A displays a dimorphism at residue 158. The allele V158 encodes a higher Fc affinity receptor variant while the allele F158 encodes a lower Fc affinity receptor variant. FcGR3A (CD16a) plays a role in the activation of natural killer (NK) cells, and it is extensively used as a cell marker. Its expression has also been observed at the surface of T cells in patients with chronic viral infections (such as COVID-19). Binding to CD16a can potentiate the efficacy of therapeutic antibodies used to treat solid tumors. In addition, CD16a is a biomarker in hematopoietic cancers and an interesting therapeutic target.
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