TRKB Kinase Assay Kit
The TRKB Kinase Assay Kit is designed to measure TRKB kinase activity for screening and profiling applications using ADP-Glo® as a detection reagent.
- ADP-Glo® Kinase Assay (Promega #V6930)
- Microplate reader capable of reading luminescence
- Adjustable micropipettor and sterile tips
- 30°C Incubator
| Catalog # | Name | Amount | Storage |
| 40281 | TRKB* | 10 µg | -80°C |
| 79334 | Kinase Buffer 1 (5x) | 1.5 ml | -20°C |
| 79686 | ATP (500 µM) | 50 µl | -20°C |
| 40217 | PTK Substrate (Poly-Glu,Tyr 4:1) (10 mg/ml) | 50 µl | -20°C |
| White 96-well plate | 1 | Room Temp |
*The concentration of the protein is lot-specific and will be indicated on the tube
Tropomyosin receptor kinase B (TRKB) is a high-affinity catalytic receptor for neurotrophins and is part of a large family of tyrosine kinases. Once activated by specific neurotrophins, such as brain derived neurotrophic factor (BDNF), TRKB mediates neuronal differentiation and survival. TRKB and BDNF have been associated with the pathology and progression of Alzheimer’s disease and other neurodegenerative disorders. More recently as a member of TRK proto-oncogene family, TRKB inhibitors have become of interest as a possible cancer therapy.
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