TCR Knockout Jurkat Cell Line
TCR Knockout Jurkat Cell Line is a Jurkat cell line generated by CRISPR/Cas9 genome editing to remove the TRAC (T-Cell Receptor Alpha Constant) and TRBC1 (T-Cell Receptor Beta Constant 1) domains of the TCRα and β chains.
Purchase of this cell line is for research purposes only; commercial use requires a separate license. View the full terms and conditions.
| Name | Ordering Information |
| Thaw Medium 2 | BPS Bioscience #60184 |
The cell line has been screened to confirm the absence of Mycoplasma species.
The T-Cell Receptor (TCR) is found on the surface of T cells and is responsible for recognizing antigens bound to MHC (Major Histocompatibility Complex) molecules. Engagement of the TCR initiates downstream NFAT (nuclear factor of activator T cells) signaling resulting in T cell activation. The TCR consists of a heterodimer of two different protein chains, of which the alpha (α) and beta (β) chains are the predominant chains. CRISPR/Cas9 genome editing was utilized to remove the TRAC (T-Cell Receptor Alpha Constant) and TRBC1 (T-Cell Receptor Beta Constant 1) regions of the α and β chains, resulting in a loss of TCR expression.
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