STING, GST-Tag, His-Tag Recombinant
Recombinant human STING (stimulator of interferon genes), encompassing amino acids 139-344. This construct contains an N-terminal GST tag followed by a Thrombin Cleavage Site and a C-terminal His-tag (6xHis). This protein was affinity purified.
≥90%
Aqueous buffer solution.
40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, 20% glycerol, and varaible Imidazole
STING (stimulator of interferon genes), also known as TMEM173 (transmembrane protein 173), is a crucial protein in innate immunity. It is a membrane protein involved in the response to foreign DNA in hematopoietic lineage cells, such as NK and T cells, myeloid cells, and monocytes. It is also found in the retina, heart, and other tissues. STING gets activated by DNA sensors and triggers IFN (type I interferon) production, by stimulating TBK1, which then phosphorylates STAT6 (signal transducer and activator of transcription 6) or IRF3 (interferon regulatory factor 3). These in turn activate the expression of genes linked to immune responses. It can also function as a DNA sensor, by binding directly to the cyclic di-GMP. More recently STING’s role in controlling ROS (reactive oxygen species) formation and that loss of STING reduces DNA damage have been identified. The development the STING agonist that be beneficial in combinatory cancer therapy.
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