GPRC5D CHO Cell Line
Recombinant CHO-K1 cells stably expressing human GPRC5D (NM_018654.1) under the control of a CMV promoter.
Purchase of this cell line is for research purposes only; commercial use requires a separate license. View the full terms and conditions.
| Name | Ordering Information |
| Thaw Medium 3 | BPS Bioscience #60186 |
| Growth Medium 3B | BPS Bioscience #79529 |
For best results, it is highly recommended to use these validated and optimized media from BPS Bioscience. Other preparations or formulations of media may result in suboptimal performance.
Thaw Medium 3 (BPS Bioscience, #60186):
F-12K Medium (Kaighn's Modification of Ham's F-12 Medium) supplemented with 10% FBS, 1% Penicillin/Streptomycin
Growth Medium 3B (BPS Bioscience #79529):
F-12K Medium (Kaighn's Modification of Ham's F-12 Medium) supplemented with 10% FBS, 1% Penicillin/Streptomycin plus 500 μg/ml of Hygromycin B
The cell line has been screened to confirm the absence of Mycoplasma species.
The orphan G protein–coupled receptor, class C group 5 member D (GPRC5D) is a retinoic acid-inducible protein with seven transmembrane segments and a short N-terminal extracellular region. The strong and selective expression of GPRC5D in Multiple Myeloma cells, similar to the expression pattern of B-cell maturation antigen (BCMA), makes it a promising target for the treatment of Multiple Myeloma. It is anticipated that GPRC5D will be an alternative CAR T cell target for Multiple Myeloma immunotherapy.
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