GPRC5D HEK293 Cell Line
Recombinant HEK293 cells constitutively expressing human GPRC5D (the orphan G protein–coupled receptor, class C group 5 member D, NM_018654.1) under the control of a CMV promoter.
Purchase of this cell line is for research purposes only; commercial use requires a separate license. View the full terms and conditions.
| Name | Ordering Information |
| Thaw Medium 1 | BPS Bioscience #60187 |
| Growth Medium 1C | BPS Bioscience #79532 |
For best results, it is highly recommended to use these validated and optimized media from BPS Bioscience. Other preparations or formulations of media may result in suboptimal performance.
Thaw Medium 1 (BPS Bioscience #60187):
MEM medium supplemented with 10% FBS, 1% non-essential amino acids, 1 mM Na pyruvate, 1% Penicillin/Streptomycin.
Growth Medium 1C (BPS Bioscience #79532):
MEM medium supplemented with 10% FBS, 1% non-essential amino acids, 1 mM Na pyruvate, 1% Penicillin/Streptomycin plus 50 µg/ml of Hygromycin B
The cell line has been screened to confirm the absence of Mycoplasma species.
The orphan G protein–coupled receptor, class C group 5 member D (GPRC5D) is a retinoic acid-inducible protein with seven transmembrane segments and a short N-terminal extracellular region. The strong and selective expression of GPRC5D in Multiple Myeloma cells, similar to the expression pattern of B-cell maturation antigen (BCMA), makes it a promising target for the treatment of Multiple Myeloma. It is anticipated that GPRC5D will be an alternative CAR T cell target for Multiple Myeloma immunotherapy.
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