MMP12 Fluorogenic Assay Kit
The Fluorogenic MMP12 Assay Kit is designed to measure MMP12 activity for screening and profiling applications, in a homogeneous assay with no time-consuming washing steps.
Need us to run inhibitor screens or profile your compounds against MMP12? Check out our Protease Screening Services.
Fluorescent microplate reader capable of reading exc/em=328 nm/393 nm
| Catalog Number |
Component |
Amount |
Storage |
|
| MMP12 | 3 µg | -80°C | Avoid freeze/ thaw cycles! |
|
| 79919 | MMP Substrate (1 mM) | 10 µl | -80°C | |
| 79917 | 1X MMP Assay Buffer 1 | 25 ml | -20°C | |
| 79685 | Black, low binding black microtiter plate | 1 | Room Temp |
|
MMP12 (matrix metalloproteinase 12) is a member of the matrix metalloproteinase (MMP) family involved in the degradation of the extracellular matrix. MMP12 is also associated with the regulation of cytokines and chemokines, suggesting a role for MMP12 in inflammation. MMP12 is also essential for arterial stiffening in mice and is a highly prognostic marker of arterial stiffness, making MMP12 a therapeutic target for cardiovascular disease.
1. Morris, D.G., et al. 2003. "Loss of integrin αvβ6-mediated TGF-β activation causes MMP12-dependent emphysema." Nature 422(6928): 169-173.
2. Hunninghake, G.M., et al. 2009. "MMP12, lung function, and COPD in high-risk populations." New England Journal of Medicine 361(27): 2599-2608.
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